Observational studyInvestigative ophthalmology & visual science2016
Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography.
Observational study in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluation of retina and microvascular changes in the patient with Parkinson's disease: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Quantifying Choriocapillaris Flow Deficits in Diabetic Retinopathy Using Projection-Resolved OCT Angiography.Investigative ophthalmology & visual science · 2025Article
- Retinal neurovascular coupling evaluation with circular-scan OCTA.Optics express · 2025Article
- Ultra-Widefield Retinal Optical Coherence Tomography (OCT) and Angio-OCT Using an Add-On Lens.Diagnostics (Basel, Switzerland) · 2025Article
- Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography.Translational vision science & technology · 2025Article
- Glaucomatous Focal Perfusion Loss in the Macula Measured by Optical Coherence Tomographic Angiography.American journal of ophthalmology · 2024Article
- Robust Ultrafast Projection Pipeline for Structural and Angiography Imaging of Fourier-Domain Optical Coherence Tomography.Diagnostics (Basel, Switzerland) · 2024Article
- Optical coherence tomography angiography in diabetic retinopathy.Progress in retinal and eye research · 2023Review
- Quantification of microvascular change of retinal degeneration in Royal College of Surgeons rats using high-resolution spectral domain optical coherence tomography angiography.Journal of biomedical optics · 2023Article
- OCT angiography and its retinal biomarkers [Invited].Biomedical optics express · 2023Review
- Sector-Based Regression Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.Translational vision science & technology · 2023Article
- Signal attenuation-compensated projection-resolved OCT angiography.Biomedical optics express · 2023Article
- Deep learning-based signal-independent assessment of macular avascular area on 6×6 mm optical coherence tomography angiogram in diabetic retinopathy: a comparison to instrument-embedded software.The British journal of ophthalmology · 2023Article
- Optical coherence tomographic angiography detects retinal vascular changes associated with pituitary adenoma.American journal of ophthalmology case reports · 2022Article
- The role of optical coherence tomography angiography in distinguishing ischemic versus non-ischemic central retinal vein occlusion.BMC ophthalmology · 2022Article
- Regression-Based Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.Translational vision science & technology · 2022Article
- Endoscopic optical coherence tomography angiography using inverse SNR-amplitude decorrelation features and electrothermal micro-electro-mechanical system raster scan.Quantitative imaging in medicine and surgery · 2022Article
- Impact of signal strength on quantitative retinal and choriocapillaris flow measurement from optical coherence tomography angiography.Scientific reports · 2022Article
- Artificial intelligence in OCT angiography.Progress in retinal and eye research · 2021Review
- Cognitive decline in older adults: What can we learn from optical coherence tomography (OCT)-based retinal vascular imaging?Journal of the American Geriatrics Society · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeTo compensate for reflectance variation when quantifying vessel density by optical coherence tomography angiography (OCTA).
methodsHealthy participants received 6×6-mm macular and 4.5×4.5-mm optic nerve head (ONH) angiography scans on a 70-kHz spectral-domain optical coherence tomography system. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute the OCTA signal. Mean reflectance projection and maximum decorrelation projection were used to create en face OCT and OCTA images. Background OCTA noise in static tissue was evaluated in the foveal avascular zone (FAZ). Vessel density was calculated from en face retinal OCTA that was binarized according to a decorrelation threshold.
resultsThe average retinal decorrelation noise in the FAZ was linearly related to the average logarithmic-scale OCT reflectance signal. Based on this relationship, a reflectance-adjusted decorrelation threshold equation was developed to filter out 97.5% of background OCTA noise. A fixed threshold was also used for comparison. The superficial vascular complex vessel density in the macula and ONH were significantly correlated with reflectance signal strength index (SSI) using the fixed threshold. This correlation was removed by using the reflectance-adjusted threshold. Reflectance compensation reduced population variation in 25 healthy eyes from 8.5% to 4.8% (coefficient of variation) in the macula and from 6.7% to 5.4% in the peripapillary region. Within-visit repeatability also improved from 4.4% to 1.8% in the macula and from 3% to 1.7% in the peripapillary region.
conclusionsCompensating for reflectance variation resulted in more reliable vessel density quantification in OCTA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.