ArticleStem cells (Dayton, Ohio)2016
Irx4 Marks a Multipotent, Ventricular-Specific Progenitor Cell.
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Article in Stem cells (Dayton, Ohio), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Synonymous variants in IRX4 and their association with congenital heart disease: an in-silico functional assessment.Molecular biology reports · 2026Article
- Understanding normal cardiac morphogenesis and its disruptions: a journey through pathways.Frontiers in genetics · 2026Review
- Multifaceted role of Iroquois signaling in development and diseases.Molecules and cells · 2025Review
- Review
- In-Depth Genomic Analysis: The New Challenge in Congenital Heart Disease.International journal of molecular sciences · 2024Review
- Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias.Nature cardiovascular research · 2024Article
- Unravelling the Role of Iroquois Homeobox 4 and its Interplay with Androgen Receptor in Prostate Cancer.Research square · 2023Article
- Generation of cardiomyocytes from human-induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Article
- Whole exome sequencing with a focus on cardiac disease-associated genes in families of sudden unexplained deaths in Yunnan, southwest of China.BMC genomics · 2023Article
- Integrating Genomic and Transcriptomic Data to Reveal Genetic Mechanisms Underlying Piao Chicken Rumpless Trait.Genomics, proteomics & bioinformatics · 2021Article
- Myosin light chain 2 marks differentiating ventricular cardiomyocytes derived from human embryonic stem cells.Pflugers Archiv : European journal of physiology · 2021Article
- Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis.Nature communications · 2021Article
- Placental proteome abnormalities in women with gestational diabetes and large-for-gestational-age newborns.BMJ open diabetes research & care · 2020Article
- Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling.Cancers · 2020Article
- Clinical and molecular characterization of 12 prenatal cases of Cri-du-chat syndrome.Molecular genetics & genomic medicine · 2020Article
- miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations.International journal of molecular sciences · 2020Article
- DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs.Clinical epigenetics · 2019Article
- Regenerative potential of mouse embryonic stem cell-derived PDGFRαWorld journal of stem cells · 2019Article
- Generation of multipotent induced cardiac progenitor cells from mouse fibroblasts and potency testing in ex vivo mouse embryos.Nature protocols · 2017Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Daryl O NelsonDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Pratik A LalitDepartment of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA.
Mitch BiermannDepartment of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA.
Yogananda S MarkandeyaDepartment of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA.
Deborah L CapesDepartment of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA.
Luke AddessoDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Gina PatelDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Tianxiao HanDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Manorama C JohnUniversity of Wisconsin Biotechnology Center, University of Wisconsin, Madison, Wisconsin, USA.
Patricia A PowersUniversity of Wisconsin Biotechnology Center, University of Wisconsin, Madison, Wisconsin, USA.
Karen M DownsDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Timothy J KampDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Gary E LyonsDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
University of Wisconsin–Madison · US
Funding
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2MINTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3MMidwest Progenitor Cell ConsortiumU01HL099773 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI THOMSON, JAMES ALEXANDER · 2009 to 2015
$7.8MMorphogenesis of the chorio-allantoic placenta II: The Allantoic Core DomainR01HD042706 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI DOWNS, KAREN M · 2002 to 2012
$3.0MEmbryonic Stem Cell-based Therapies for Myocardial InfarctionR01HL084615 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI KAMP, TIMOTHY J. · 2007 to 2010
$1.6MThe fetal-umbilical connection: role of hypoblast/visceral endodermR01HD079481 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI GREENSPAN, DANIEL S · 2014 to 2018
$1.5MRefining Cardiac Progenitor Cells for Myocardial RepairR01HL129798 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI KAMP, TIMOTHY J. · 2015 to 2018
$1.5MInstitutional Clinical and Translational Science AwardTL1TR000429 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$1.5MOlympus FV1000 Livecell Confocal SystemS10RR025644 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI KAMP, TIMOTHY J. · 2011 to 2011
$433kAssessing Disease Activity in IPF with Novel Biomarkers and Molecular ImagingF32HL129789 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MONTESI, SYDNEY · 2015 to 2016
$131kIdentification of a Ventricular Progenitor using Irx4 as a genetic markerF31HL105109 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI NELSON, DARYL O'NEIL · 2010 to 2012
$89kNCATS NIH HHS TL1 TR000429NCATS NIH HHS UL1 TR000427NCRR NIH HHS S10 RR025644NHLBI NIH HHS F31 HL105109NHLBI NIH HHS F32 HL129789NHLBI NIH HHS R01 HL084615NHLBI NIH HHS R01 HL129798NHLBI NIH HHS U01 HL099773NICHD NIH HHS R01 HD042706NICHD NIH HHS R01 HD079481NIGMS NIH HHS T32 GM008692
Abstract
While much progress has been made in the resolution of the cellular hierarchy underlying cardiogenesis, our understanding of chamber-specific myocardium differentiation remains incomplete. To better understand ventricular myocardium differentiation, we targeted the ventricle-specific gene, Irx4, in mouse embryonic stem cells to generate a reporter cell line. Using an antibiotic-selection approach, we purified Irx4
Indexed as
AnimalsBiomarkersCell LineCell MembraneCell ProliferationCell SeparationClone CellsEmbryonic DevelopmentEndothelial CellsGene Expression Regulation, DevelopmentalGenes, ReporterHeart VentriclesHomeodomain ProteinsMiceMouse Embryonic Stem CellsMultipotent Stem CellsBiomarkersHomeodomain ProteinsIrx4 protein, mouseCardiacDevelopmental biologyDifferentiationEmbryonic stem cellsProgenitor cellsStem cell transplantation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.