Evidence map›Paper›PMID 27570841›Full record

ArticleInternational journal of stem cell research and therapy

Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell Clones is Defined by the Promoter CpG Methylation Pattern Observed by High-Throughput Methylation Specific Sequencing.

Jonathan Kenyon, Gabrielle Nickel-Meester, Yulan Qing, Gabriela Santos-Guasch, Ellen Drake, PingfuFu, Shuying Sun, Xiaodong Bai, David Wald, Eric Arts and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cell research and therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Role ofOncoTargets and therapy · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jonathan KenyonDepartment of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA; Division of Hematology and Oncology, Case Western Reserve University, Cleveland, OH, 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA.
Gabrielle Nickel-MeesterDivision of Infectious Disease, Department of Medicine, Case School of Medicine and the Center for AIDS Research, Case Western Reserve University, Cleveland, OH, 44106, USA.
Yulan QingDivision of Hematology and Oncology, Case Western Reserve University, Cleveland, OH, 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA.
Gabriela Santos-GuaschDivision of Hematology and Oncology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Ellen DrakeDivision of Hematology and Oncology, Case Western Reserve University, Cleveland, OH, 44106, USA.
PingfuFuDepartment of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, OH, 44106, USA.
Shuying SunDepartment of Mathematics, Texas State University, San Marcos, TX, 78666, USA.
Xiaodong BaiRNA Center, Case Western Reserve University, Cleveland, OH, 44106, USA.
David WaldCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA; Center for Stem Cell and Regenerative Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, 44106, USA.
Eric ArtsDivision of Infectious Disease, Department of Medicine, Case School of Medicine and the Center for AIDS Research, Case Western Reserve University, Cleveland, OH, 44106, USA.
Stanton L GersonDepartment of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA; Division of Hematology and Oncology, Case Western Reserve University, Cleveland, OH, 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA; Center for Stem Cell and Regenerative Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, 44106, USA; Seidman Cancer Center, University Hospitals of Cleveland, Cleveland, OH, 44106, USA.
Case Western Reserve University · US

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARK R CHANCE · 1987 to 2026
$142.3M
Declining DNA repair in Aging Hematopoietic Stem CellR01AG024916 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI GERSON, STANTON L. · 2004 to 2008
$1.6M
NCI NIH HHS P30 CA043703NIA NIH HHS R01 AG024916
6 · The paper itself

Abstract

Normal human hematopoietic stem and progenitor cells (HPC) lose expression of

Indexed as

EpigeneticsHematopoietic stem cellsHigh throughput bisulfite sequencingMismatch repair

Identifiers

PMID27570841
PMCPMC4996274
OpenAlexW2515378946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.