ArticleeNeuro
Type II Cochlear Ganglion Neurons Do Not Drive the Olivocochlear Reflex: Re-Examination of the Cochlear Phenotype in Peripherin Knock-Out Mice.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Cochlear histopathology in macaques after noise-induced temporary threshold shifts.Hearing research · 2026Article
- A Diphtheria Toxin-Induced Mouse Model of Auditory Neuropathy: From Cochlear Synaptopathy to Neuronal Degeneration.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Expression of the P2X1 receptor remains in the type II spiral ganglion neurons in the mature rat cochlea.Purinergic signalling · 2026Article
- ATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Damage-evoked signals in cochlear neurons and supporting cells.Frontiers in neurology · 2024Review
- ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Noise-induced hearing loss vulnerability in type III intermediate filament peripherin gene knockout mice.Frontiers in neurology · 2022Article
- Cytoarchitecture and innervation of the mouse cochlear amplifier revealed by large-scale volume electron microscopy.The Journal of comparative neurology · 2021Article
- Changes in the Gene Expression Profiles of the Inferior Colliculus Following Unilateral Cochlear Ablation in Adult Rats.Biochemical genetics · 2021Article
- Efferent feedback controls bilateral auditory spontaneous activity.Nature communications · 2021Article
- Developmental Changes inFrontiers in cellular neuroscience · 2021Article
- Deletion ofFrontiers in cellular neuroscience · 2021Article
- Axodendritic versus axosomatic cochlear efferent termination is determined by afferent type in a hierarchical logic of circuit formation.Science advances · 2021Article
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- Recent development of AAV-based gene therapies for inner ear disorders.Gene therapy · 2020Review
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- Coordinated calcium signalling in cochlear sensory and non-sensory cells refines afferent innervation of outer hair cells.The EMBO journal · 2019Article
- Talking back: Development of the olivocochlear efferent system.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea.Development (Cambridge, England) · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The cochlear nerve includes a small population of unmyelinated sensory fibers connecting outer hair cells to the brain. The functional role of these type II afferent neurons is controversial, because neurophysiological data are sparse. A recent study (Froud et al., 2015) reported that targeted deletion of peripherin, a type of neurofilament, eliminated type II afferents and inactivated efferent feedback to the outer hair cells, thereby suggesting that type II afferents were the sensory drive to this sound-evoked, negative-feedback reflex, the olivocochlear pathway. Here, we re-evaluated the cochlear phenotype in mice from the peripherin knock-out line and show that (1) type II afferent terminals are present in normal number and (2) olivocochlear suppression of cochlear responses is absent even when this efferent pathway is directly activated by shocks. We conclude that type II neurons are not the sensory drive for the efferent reflex and that peripherin deletion likely causes dysfunction of synaptic transmission between olivocochlear terminals and their peripheral targets.
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