ArticleArtery research2016
Loss of Elastic Fiber Integrity Compromises Common Carotid Artery Function: Implications for Vascular Aging.
Article in Artery research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Biomechanical and Compositional Changes in the Murine Uterus with Age.Annals of biomedical engineering · 2025Article
- Vascular Remodeling During Late-Gestation Pregnancy: An In-Vitro Assessment of the Murine Ascending Thoracic Aorta.Journal of biomechanical engineering · 2024Article
- Implications of preoperative arterial stiffness for patients treated with endovascular repair of abdominal aortic aneurysms.JVS-vascular science · 2024Review
- TheFrontiers in cardiovascular medicine · 2024Article
- Lengthwise regional mechanics of the human aneurysmal ascending thoracic aorta.Acta biomaterialia · 2023Article
- Biaxial Murine Vaginal Remodeling With Reproductive Aging.Journal of biomechanical engineering · 2022Article
- Scaffold Geometry-Imposed Anisotropic Mechanical Loading Guides the Evolution of the Mechanical State of Engineered Cardiovascular TissuesFrontiers in bioengineering and biotechnology · 2022Article
- Sex and the G Protein-Coupled Estrogen Receptor Impact Vascular Stiffness.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Comparative Study of Human and Murine Aortic Biomechanics and Hemodynamics in Vascular Aging.Frontiers in physiology · 2021Article
- Caught between a "Rho" and a hard place: are CCN1/CYR61 and CCN2/CTGF the arbiters of microvascular stiffness?Journal of cell communication and signaling · 2020Review
- Article
- Sex-dependent differences in central artery haemodynamics in normal and fibulin-5 deficient mice: implications for ageing.Proceedings. Mathematical, physical, and engineering sciences · 2019Article
- Initial scaffold thickness affects the emergence of a geometrical and mechanical equilibrium in engineered cardiovascular tissues.Journal of the Royal Society, Interface · 2018Article
- New insights into arterial stiffening: does sex matter?American journal of physiology. Heart and circulatory physiology · 2018Review
- Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences.Biomechanics and modeling in mechanobiology · 2018Article
- Role of Thioredoxin in Age-Related Hypertension.Current hypertension reports · 2018Review
- Elastic Fibers and Large Artery Mechanics in Animal Models of Development and Disease.Journal of biomechanical engineering · 2018Review
- Proinflammatory Arterial Stiffness Syndrome: A Signature of Large Arterial Aging.Journal of vascular research · 2018Review
- Differential cell-matrix mechanoadaptations and inflammation drive regional propensities to aortic fibrosis, aneurysm or dissection in hypertension.Journal of the Royal Society, Interface · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Competent elastic fibers endow central arteries with the compliance and resilience that are fundamental to their primary mechanical function in vertebrates. That is, by enabling elastic energy to be stored in the arterial wall during systole and then to be used to work on the blood during diastole, elastic fibers decrease ventricular workload and augment blood flow in pulsatile systems. Indeed, because elastic fibers are formed during development and stretched during somatic growth, their continual tendency to recoil contributes to the undulation of the stiffer collagen fibers, which facilitates further the overall compliance of the wall under physiologic pressures while allowing the collagen to limit over-distension during acute increases in blood pressure. In this paper, we use consistent methods of measurement and quantification to compare the biaxial material stiffness, structural stiffness, and energy storage capacity of murine common carotid arteries having graded degrees of elastic fiber integrity - normal, elastin-deficient, fibrillin-1 deficient, fibulin-5 null, and elastase-treated. The finding that the intrinsic material stiffness tends to be maintained nearly constant suggests that intramural cells seek to maintain a favorable micromechanical environment in which to function. Nevertheless, a loss of elastic energy storage capability due to the loss of elastic fiber integrity severely compromises the primary function of these central arteries.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.