ArticleCell2016
Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity.
Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
88 citing papers in PubMed, 165 citations in OpenAlex.
- CabioRxiv : the preprint server for biology · 2026Article
- A multiomics atlas of theScience advances · 2026Article
- SUMO E3 ligase SIZ1 promotes nuclear condensate-mediated immune activation in Arabidopsis.Nature communications · 2026Article
- The role of phase separation for RNA and protein transport through the nuclear pore complex.Journal of experimental botany · 2026Review
- In situ architecture of the nuclear pore complex of the higher plant Arabidopsis thaliana.Nature plants · 2025Article
- Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic transport.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A nucleoporin-associated signaling cascade controls plant immunity via histone modification.Genome biology · 2025Article
- Overexpression of the Receptor-Like Kinase BIR1 Causes SOBIR1- and EDS1-Dependent Cell Death Phenotypes in Arabidopsis.Plant, cell & environment · 2025Article
- ECLIPSE mediates selective degradation of inner nuclear membrane protein in plants.Journal of experimental botany · 2025Article
- The pathogen effector BcSSP2 suppresses the NPC phase separation to facilitate Botrytis cinerea infection.Nature communications · 2025Article
- Phosphorylation of CPR5 by the receptor-like kinase FLR2 promotes mRNA poly(A) tail processing and immunity to Magnaporthe oryzae in rice.Plant communications · 2025Article
- The Nucleoporin CPR5 Modulates Plant Immunity via Guanylate-Binding Proteins.Molecular plant pathology · 2025Article
- Nucleoporin PNET1 coordinates mitotic nuclear pore complex dynamics for rapid cell division.Nature plants · 2025Article
- Identification and Application of the Heptad Repeat Domain in the CPR5 Protein for Enhancing Plant Immunity.Molecular plant pathology · 2025Article
- Article
- PCV2 Cap protein nuclear import via importin α/β receptor: molecular insights and antiviral potential.Frontiers in microbiology · 2025Article
- Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response.PLoS pathogens · 2024Article
- Rice Yellow Mottle Virus (RYMV): A Review.Viruses · 2024Review
- Altering cold-regulated gene expression decouples the salicylic acid-growth trade-off in Arabidopsis.The Plant cell · 2024Article
- mProceedings of the National Academy of Sciences of the United States of America · 2024Article
28 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Nuclear transport of immune receptors, signal transducers, and transcription factors is an essential regulatory mechanism for immune activation. Whether and how this process is regulated at the level of the nuclear pore complex (NPC) remains unclear. Here, we report that CPR5, which plays a key inhibitory role in effector-triggered immunity (ETI) and programmed cell death (PCD) in plants, is a novel transmembrane nucleoporin. CPR5 associates with anchors of the NPC selective barrier to constrain nuclear access of signaling cargos and sequesters cyclin-dependent kinase inhibitors (CKIs) involved in ETI signal transduction. Upon activation by immunoreceptors, CPR5 undergoes an oligomer to monomer conformational switch, which coordinates CKI release for ETI signaling and reconfigures the selective barrier to allow significant influx of nuclear signaling cargos through the NPC. Consequently, these coordinated NPC actions result in simultaneous activation of diverse stress-related signaling pathways and constitute an essential regulatory mechanism specific for ETI/PCD induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.