Evidence map›Paper›PMID 27569707›Full record

ReviewPhytochemistry2016

Regulation of plant secondary metabolism and associated specialized cell development by MYBs and bHLHs.

William R Chezem, Nicole K Clay

Abstract readReview
In one paragraph

Review in Phytochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Biological Characteristics of a Novel Bibenzyl Synthase (Molecules (Basel, Switzerland) · 2024
    Article
  13. Review
  14. The R2R3-MYB Transcriptional RepressorInternational journal of molecular sciences · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Enhancing Centelloside Production inPlants (Basel, Switzerland) · 2023
    Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

William R ChezemDepartment of Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT, USA. Electronic address: william.chezem@yale.edu.
Nicole K ClayDepartment of Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT, USA. Electronic address: nicole.clay@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007499 · NIGMS · YALE UNIVERSITY · PI CARLSON, JOHN R, REINKE, VALERIE J · 1985 to 2022
$13.9M
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS T32 GM007499
6 · The paper itself

Abstract

Plants are unrivaled in the natural world in both the number and complexity of secondary metabolites they produce, and the ubiquitous phenylpropanoids and the lineage-specific glucosinolates represent two such large and chemically diverse groups. Advances in genome-enabled biochemistry and metabolomic technologies have greatly increased the understanding of their metabolic networks in diverse plant species. There also has been some progress in elucidating the gene regulatory networks that are key to their synthesis, accumulation and function. This review highlights what is currently known about the gene regulatory networks and the stable sub-networks of transcription factors at their cores that regulate the production of these plant secondary metabolites and the differentiation of specialized cell types that are equally important to their defensive function. Remarkably, some of these core components are evolutionarily conserved between secondary metabolism and specialized cell development and across distantly related plant species. These findings suggest that the more ancient gene regulatory networks for the differentiation of fundamental cell types may have been recruited and remodeled for the generation of the vast majority of plant secondary metabolites and their specialized tissues.

Indexed as

Gene Expression Regulation, PlantArabidopsis ProteinsBasic Helix-Loop-Helix ProteinsGlucosinolatesLigninPlant ProteinsProto-Oncogene Proteins c-mybSecondary MetabolismArabidopsis ProteinsBasic Helix-Loop-Helix ProteinsGlucosinolatesLigninPlant ProteinsProto-Oncogene Proteins c-mybbHLHFlavonoidGlucosinolateGuard cells in stomataLaticiferLigninMyrosin idioblastPhenylpropanoidR2R3-type MYBR3-type MYBWD40

Identifiers

PMID27569707
PMCPMC5048601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.