ArticleAddictive behaviors2017
Medical and nonmedical use of prescription sedatives and anxiolytics: Adolescents' use and substance use disorder symptoms in adulthood.
Article in Addictive behaviors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The epidemiology of benzodiazepine misuse: A systematic review.Drug and alcohol dependence · 2019Pooled it
- Incident benzodiazepine and Z-drug use and subsequent risk of alcohol- and drug-related problems: A nationwide matched cohort study with co-twin comparison.Journal of psychopharmacology (Oxford, England) · 2026Article
- Maturing out or in? Demographic determinants of young adult drinking trajectories and midlife alcohol use disorder risks.Alcohol, clinical & experimental research · 2026Article
- Prescribing of controlled substances to adolescents and young adults enrolled in Medicaid, 2001-2019.Drug and alcohol dependence · 2026Article
- Nationwide trends in diagnosed sedative, hypnotic or anxiolytic use disorders in adolescents and young adults enrolled in Medicaid: 2001-2019.Addiction (Abingdon, England) · 2025Article
- Characteristics of high-dose benzodiazepine use: nationwide cohort study on new benzodiazepine users with 5-year follow-up.BJPsych open · 2024Article
- Changing patterns of hospitalization for sedative misuse among youth aged 10-24 years in Quebec, Canada.Drug and alcohol dependence reports · 2024Article
- Article
- Age 19-30 Union Formation Trajectories across the Past 30 Years within the U.S.: Delineating Heterogeneity in Trajectories and its Historical and Sociodemographic Variation.Research in human development · 2024Article
- Cohort effects of women's mid-life binge drinking and alcohol use disorder symptoms in the United States: Impacts of changes in timing of parenthood.Addiction (Abingdon, England) · 2023Article
- Suicide Attempt and Risk of Substance Use Disorders Among Female Youths.JAMA psychiatry · 2022Article
- Cohort and age trends in age 35-45 prevalence of alcohol use disorder symptomology, by severity, sex, race, and education.Drug and alcohol dependence · 2021Article
- Effects of depression, anxiety and screen use on adolescent substance use.Preventive medicine reports · 2021Article
- Poly-prescription drug misuse across the life course: Prevalence and correlates across different adult age cohorts in the U.S.The International journal on drug policy · 2021Article
- Personality to Prescription Drug Misuse in Adolescents: Testing Affect Regulation, Psychological Dysregulation, and Deviance Proneness Pathways.Frontiers in psychiatry · 2021Article
- Desistance, Self-treatment, or Substitution: Decisions about Cannabis Use During Pregnancy.Journal of midwifery & women's health · 2021Article
- The Long-Term Associations Between Direct and Threatened Physical Violence in Adolescence and Symptoms of Substance Use Disorders During the Mid-30s.Journal of studies on alcohol and drugs · 2020Article
- Prescription Drug Misuse: Taking a Lifespan Perspective.Substance abuse : research and treatment · 2020Review
- Sex differences in nonmedical prescription tranquilizer and stimulant use trends among secondary school students in Argentina, Chile, and Uruguay.Drug and alcohol dependence · 2019Article
- Gender differences in the nonmedical use of psychoactive medications in the school population- national trends and related factors.BMC pediatrics · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesThis study assessed the longitudinal associations between medical and nonmedical use of prescription sedatives/anxiolytics (NMPSA) during adolescence (age 18) and substance use disorder (SUD) symptoms during adulthood (age 35).
methodsMultiple cohorts of nationally representative samples of U.S. high school seniors (n=8373) were surveyed via self-administered questionnaires and followed longitudinally from adolescence (age 18, 1976-1996) to adulthood (age 35, 1993-2013).
resultsAn estimated 20.1% of adolescents reported lifetime medical or nonmedical use of prescription sedatives/anxiolytics. Among adolescents who reported medical use of prescription sedatives/anxiolytics, 44.9% also reported NMPSA by age 18. Based on multivariate analyses that included age 18 sociodemographic and other substance use controls, medical use of prescription sedatives/anxiolytics without any history of NMPSA during adolescence was not associated with SUD symptoms in adulthood relative to adolescents with no prescription sedative/anxiolytic use. In contrast, adolescents with a history of both medical and nonmedical use of prescription sedatives/anxiolytics and adolescents who reported only NMPSA had between two to three times greater odds of SUD symptoms in adulthood relative to adolescents with no prescription sedative/anxiolytic use and those who reported only medical use of prescription sedatives/anxiolytics.
conclusionsOne in every five U.S. high school seniors reported ever using prescription sedatives/anxiolytics either medically or nonmedically. This study provides compelling evidence that the medical use of prescription sedatives/anxiolytics (without any NMPSA) during adolescence is not associated with increased risk of SUD symptoms in adulthood while any NMPSA during adolescence serves as a signal for SUDs in adulthood.
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