ArticleInternational journal for numerical methods in biomedical engineering2017
Hemodynamics-driven deposition of intraluminal thrombus in abdominal aortic aneurysms.
Article in International journal for numerical methods in biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Modeling Techniques and Boundary Conditions in Abdominal Aortic Aneurysm Analysis: Latest Developments in Simulation and Integration of Machine Learning and Data-Driven Approaches.Bioengineering (Basel, Switzerland) · 2025Review
- Article
- Article
- The Detrimental Role of Intraluminal Thrombus Outweighs Protective Advantage in Abdominal Aortic Aneurysm Pathogenesis: The Implications for the Anti-Platelet Therapy.Biomolecules · 2022Review
- Shear-driven modelling of thrombus formation in type B aortic dissection.Frontiers in bioengineering and biotechnology · 2022Article
- Computational modeling of blood component transport related to coronary artery thrombosis in Kawasaki disease.PLoS computational biology · 2021Article
- Constrained Mixture Models of Soft Tissue Growth and Remodeling - Twenty Years After.Journal Of Elasticity · 2021Article
- Computational Modeling of Blood Flow Hemodynamics for Biomechanical Investigation of Cardiac Development and Disease.Journal of cardiovascular development and disease · 2021Review
- A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels.PLoS computational biology · 2020Article
- Biomechanical Investigation of Disturbed Hemodynamics-Induced Tissue Degeneration in Abdominal Aortic Aneurysms Using Computational and Experimental Techniques.Frontiers in bioengineering and biotechnology · 2019Review
- Strongly Coupled Morphological Features of Aortic Aneurysms Drive Intraluminal Thrombus.Scientific reports · 2018Article
- Toward modeling the effects of regional material properties on the wall stress distribution of abdominal aortic aneurysms.Proceedings of SPIE--the International Society for Optical Engineering · 2018Article
- Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice.IEEE transactions on medical imaging · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Accumulating evidence suggests that intraluminal thrombus plays many roles in the natural history of abdominal aortic aneurysms. There is, therefore, a pressing need for computational models that can describe and predict the initiation and progression of thrombus in aneurysms. In this paper, we introduce a phenomenological metric for thrombus deposition potential and use hemodynamic simulations based on medical images from 6 patients to identify best-fit values of the 2 key model parameters. We then introduce a shape optimization method to predict the associated radial growth of the thrombus into the lumen based on the expectation that thrombus initiation will create a thrombogenic surface, which in turn will promote growth until increasing hemodynamically induced frictional forces prevent any further cell or protein deposition. Comparisons between predicted and actual intraluminal thrombus in the 6 patient-specific aneurysms suggest that this phenomenological description provides a good first estimate of thrombus deposition. We submit further that, because the biologically active region of the thrombus appears to be confined to a thin luminal layer, predictions of morphology alone may be sufficient to inform fluid-solid-growth models of aneurysmal growth and remodeling.
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