SynthesisAccident; analysis and prevention2016
Medication use and the risk of motor vehicle collisions among licensed drivers: A systematic review.
Synthesis in Accident; analysis and prevention, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 106 citations in OpenAlex.
- Effects of lasmiditan on simulated driving performance: Results of two randomized, blinded, crossover studies with placebo and active controls.Human psychopharmacology · 2020Trial
- Positive Airway Pressure Therapy Initiation and Continued Benzodiazepine Use Among Chronic Drug Users.Journal of sleep research · 2026Article
- Z-Drug Use and All-Cause Mortality: A Meta-Analysis of Observational Cohort Studies.Neuropsychiatric disease and treatment · 2026Article
- Pharmacy Staff Experiences and Needs During Second Dispense of Driving-Impairing Medicines: A Qualitative Study.Pharmacy (Basel, Switzerland) · 2025Article
- The healthcare professionals' role in older adults' road safety in primary care settings in Canada: a qualitative study.BMC health services research · 2025Article
- A framework for countermeasures design to support professional drivers' fitness-to-drive.Industrial health · 2025Article
- Prevalence of Impairing Substance Use in Injured Drivers.JAMA network open · 2025Article
- A scoping review of motor vehicle operator performance assessments for benzodiazepine receptor agonists.Exploratory research in clinical and social pharmacy · 2024Article
- Medication Changes Among Older Drivers Involved in Motor Vehicle Crashes.JAMA network open · 2024Article
- Changes in the burden of medications that may impair driving among older adults before and after a motor vehicle crash.Journal of the American Geriatrics Society · 2024Observational
- Medications and traffic accidents involving older drivers: do Spanish primary healthcare physicians know enough?BMC geriatrics · 2023Article
- Trends in the Use of Driving-Impairing Medicines According to the DRUID Category: A Population-Based Registry Study with Reference to Driving in a Region of Spain between 2015 and 2019.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Risk of Motor Vehicle Collisions and Culpability among Older Drivers Using Cannabis: A Meta-Analysis.Brain sciences · 2023Review
- A protocol for a randomized controlled trial comparing Sleepwell, EMPOWER, and treatment-as-usual for benzodiazepine receptor agonist discontinuation in older adults: the your answers when needing sleep in New Brunswick (YAWNS NB) study.Exploratory research in clinical and social pharmacy · 2022Article
- Opioids and the Risk of Motor Vehicle Collision: A Systematic Review.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2022Review
- Use of potentially driver-impairing drugs among older drivers.BMC geriatrics · 2022Article
- Do opioid prescriptions lead to fatal car crashes?American journal of health economics · 2022Article
- Risk factors associated with driving under the influence of drugs in the USA.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2021Article
- Validation of the Arabic and French Versions of a Knowledge, Attitudes and Practices (KAP) Questionnaire on Tranquilizer Misuse.International journal of environmental research and public health · 2021Article
- Comparison of Longitudinal and Cross-Sectional Approaches in Studies on Knowledge, Attitude and Practices Related to Non-Medical Tranquilizer Use.Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesDriving under the influence of prescription and over-the-counter medication is a growing public health concern. A systematic review of the literature was performed to investigate which specific medications were associated with increased risk of motor vehicle collision (MVC).
methodsThe a priori inclusion criteria were: (1) studies published from English-language sources on or after January 1, 1960, (2) licensed drivers 15 years of age and older, (3) peer-reviewed publications, master's theses, doctoral dissertations, and conference papers, (4) studies limited to randomized control trials, cohort studies, case-control studies, or case-control type studies (5) outcome measure reported for at least one specific medication, (6) outcome measure reported as the odds or risk of a motor vehicle collision. Fourteen databases were examined along with hand-searching. Independent, dual selection of studies and data abstraction was performed.
resultsFifty-three medications were investigated by 27 studies included in the review. Fifteen (28.3%) were associated with an increased risk of MVC. These included Buprenorphine, Codeine, Dihydrocodeine, Methadone, Tramadol, Levocitirizine, Diazepam, Flunitrazepam, Flurazepam, Lorazepam, Temazepam, Triazolam, Carisoprodol, Zolpidem, and Zopiclone.
conclusionsSeveral medications were associated with an increased risk of MVC and decreased driving ability. The associations between specific medication use and the increased risk of MVC and/or affected driving ability are complex. Future research opportunities are plentiful and worthy of such investigation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.