Evidence map›Paper›PMID 27569542›Full record

SynthesisBiological psychiatry2016

Functional Decoding and Meta-analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder.

Samuele Cortese, F Xavier Castellanos, Claudia R Eickhoff, Giulia D'Acunto, Gabriele Masi, Peter T Fox, Angela R Laird, Simon B Eickhoff

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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  16. Attentional responses on an auditory oddball predict false memory susceptibility.Cognitive, affective & behavioral neuroscience · 2018
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 4 countries.

Samuele CorteseAcademic Unit of Psychology, Developmental Brain-Behaviour Laboratory, Southampton, United Kingdom; Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, United Kingdom; The Child Study Center, Hassenfeld Children's Hospital of New York, NYU Langone Medical Center, New York; IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Italy. Electronic address: samuele.cortese@gmail.com.
F Xavier CastellanosThe Child Study Center, Hassenfeld Children's Hospital of New York, NYU Langone Medical Center, New York; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York.
Claudia R EickhoffInstitute of Neuroscience and Medicine (INM-1), Research Center Jülich GmbH, Jülich; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen.
Giulia D'AcuntoIRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Italy.
Gabriele MasiIRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Italy.
Peter T FoxResearch Imaging Institute, University of Texas Health Science Center, San Antonio, Texas; Department of Radiology, University of Texas Health Science Center, San Antonio, Texas; South Texas Veterans Health Care System, San Antonio, Texas.
Angela R LairdDepartment of Physics, Florida International University, Miami, Florida.
Simon B EickhoffInstitute of Neuroscience and Medicine (INM-1), Research Center Jülich GmbH, Jülich; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Duesseldorf, Duesseldorf, Germany.
Istituti di Ricovero e Cura a Carattere Scientifico · ITFlorida International University · USForschungszentrum Jülich · DEHeinrich Heine University Düsseldorf · DENathan Kline Institute for Psychiatric Research · USNYU Langone Health · USThe University of Texas Health Science Center at San Antonio · US

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
Functional and Structural Connectivity in Adult Attention Deficit Hyperactivity DR01MH083246 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CASTELLANOS, FRANCISCO XAVIER · 2009 to 2011
$1.7M
NIMH NIH HHS R01 MH074457NIMH NIH HHS R01 MH083246
6 · The paper itself

Abstract

backgroundTask-based functional magnetic resonance imaging (fMRI) studies of adult attention-deficit/hyperactivity disorder (ADHD) have revealed various ADHD-related dysfunctional brain regions, with heterogeneous findings across studies. Here, we used novel meta-analytic data-driven approaches to characterize the function and connectivity profile of ADHD-related dysfunctional regions consistently detected across studies.

methodsWe first conducted an activation likelihood estimation meta-analysis of 24 task-based fMRI studies in adults with ADHD. Each ADHD-related dysfunctional region resulting from the activation likelihood estimation meta-analysis was then analyzed using functional decoding based on ~7500 fMRI experiments in the BrainMap database. This approach allows mapping brain regions to functions not necessarily tested in individual studies, thus suggesting possible novel functions for those regions. Additionally, ADHD-related dysfunctional regions were clustered based on their functional coactivation profiles across all the experiments stored in BrainMap (meta-analytic connectivity modeling).

resultsADHD-related hypoactivation was found in the left putamen, left inferior frontal gyrus (pars opercularis), left temporal pole, and right caudate. Functional decoding mapped the left putamen to cognitive aspects of music perception/reproduction and the left temporal lobe to language semantics; both these regions clustered together on the basis of their meta-analytic functional connectivity. Left inferior gyrus mapped to executive function tasks; right caudate mapped to both executive function tasks and music-related processes.

conclusionsOur study provides meta-analytic support to the hypothesis that, in addition to well-known deficits in typical executive functions, impairment in processes related to music perception/reproduction and language semantics may be involved in the pathophysiology of adult ADHD.

Indexed as

AdultAttention Deficit Disorder with HyperactivityCerebral CortexConnectomeHumansMagnetic Resonance ImagingNeostriatumAdultsAttention-deficit/hyperactivity disorderfMRIFunctional decodingMeta-analysisMeta-analytic connectivity modeling

Identifiers

PMID27569542
PMCPMC5108674
OpenAlexW2463441912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.