Evidence map›Paper›PMID 27569425›Full record

ArticleBiochemical pharmacology2016

The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4.

Xiaoxia Gao, Cen Xie, Yuanyuan Wang, Yuhong Luo, Tomoki Yagai, Dongxue Sun, Xuemei Qin, Kristopher W Krausz, Frank J Gonzalez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

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  12. Structure-Activity Relationships of the Main Bioactive Constituents ofDrug metabolism and disposition: the biological fate of chemicals · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Xiaoxia GaoModern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, Shanxi 030006, China; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: gaoxiaoxia@sxu.edu.cn.
Cen XieLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: cen.xie@nih.gov.
Yuanyuan WangBioscience Research Department, 875 Union Ave, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: ywang197@uthsc.edu.
Yuhong LuoLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: yuhong.luo@nih.gov.
Tomoki YagaiLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: tomoki.yagai@nih.gov.
Dongxue SunLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. Electronic address: dongxue.sun@nih.gov.
Xuemei QinModern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, Shanxi 030006, China. Electronic address: qinxm@sxu.edu.cn.
Kristopher W KrauszLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: krauszk@intra.nci.nih.gov.
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: gonzalef@mail.nih.gov.
Center for Cancer Research · USNational Cancer Institute · USShanxi University · CNShenyang Pharmaceutical University · CNUniversity of Tennessee Health Science Center · US

Funding

Xenobiotic receptorsZIABC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$26.9M
Xenobiotic-Metabolizing EnzymesZ01BC005562 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 1996 to 2008
$1.3M
Intramural NIH HHS Z01 BC005562
6 · The paper itself

Abstract

Flutamide (FLU), an oral, nonsteroidal antiandrogen drug used in the treatment of prostate cancer, is associated with idiosyncratic hepatotoxicity that sometimes causes severe liver damage, including cholestasis, jaundice, and liver necrosis. To understand the mechanism of toxicity, a combination of aryl hydrocarbon receptor (Ahr)-deficient (Ahr

Indexed as

AnimalsATP-Binding Cassette, Sub-Family C ProteinsBile Acids and SaltsCell Line, TumorFlutamideGene Expression RegulationHepatocytesHomeostasisLigandsMiceMice, Inbred C57BLMice, KnockoutModels, MolecularProtein BindingProtein ConformationReceptors, Aryl HydrocarbonAbcc4 protein, mouseATP-Binding Cassette, Sub-Family C ProteinsBile Acids and SaltsFlutamideLigandsReceptors, Aryl HydrocarbonABCC4Aryl hydrocarbon receptorBile acid homeostasisFlutamideMetabolomics

Identifiers

PMID27569425
PMCPMC5061623
OpenAlexW2513743034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.