Evidence map›Paper›PMID 27569118›Full record

Trial reportObesity (Silver Spring, Md.)2016

A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity.

Victoria A Catenacci, Zhaoxing Pan, Danielle Ostendorf, Sarah Brannon, Wendolyn S Gozansky, Mark P Mattson, Bronwen Martin, Paul S MacLean, Edward L Melanson, William Troy Donahoo

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03940482 (Time Restricted Eating As Treatment), which is not on this map. Cited by 178 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 20 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03940482 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Time Restricted Eating As Treatment (TREAT) for Diabetes Mellitus: A Pre-Post 12 Week Study on the Effectiveness of Intermittent Fasting in Asians With Type 2 Diabetes Mellitus

TypeinterventionalSponsorSingapore General HospitalRan2019 to 2023Enrolled50ConditionsType 2 Diabetes MellitusArmsTime Restricted Eating As Treatment (TREAT) for Diabetes.
3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 20 syntheses or guidelines pooled it, 325 citations in OpenAlex.

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  16. Intermittent fasting for the prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2021
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  18. Intermittent fasting and weight loss: Systematic review.Canadian family physician Medecin de famille canadien · 2020
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118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Victoria A CatenacciDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Zhaoxing PanDepartment of Pediatrics, Children's Hospital Colorado Research Institute, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Danielle OstendorfDepartment of Biostatistics and Informatics, Colorado School of Public Health, Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Sarah BrannonDepartment of Community and Behavioral Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Wendolyn S GozanskyKaiser Permanente, Denver, Colorado, USA.
Mark P MattsonLaboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Bronwen MartinLaboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Paul S MacLeanDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Edward L MelansonDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
William Troy DonahooDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
University of Colorado Anschutz Medical Campus · USKaiser Permanente · USChildren's Hospital Colorado · USNational Institute on Aging · USNational Institutes of Health · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Sex Hormones Differentially Regulate Production of Distinct Adipocyte PopulationP50HD073063 · NICHD · UNIVERSITY OF COLORADO DENVER · PI KOHRT, WENDY M · 2012 to 2017
$5.7M
Functional aspects of SREBP1c in intact skeletal muscleK01DK067403 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MACLEAN, PAUL S · 2005 to 2007
$397k
The Beneficial Metabolic Effects of FastingR21AT002617 · NCCIH · KAISER FOUNDATION RESEARCH INSTITUTE · PI DONAHOO, WILLIAM TROY · 2005 to 2006
$334k
NCATS NIH HHS UL1 TR001082NCCIH NIH HHS R21 AT002617NICHD NIH HHS P50 HD073063NIDDK NIH HHS K01 DK067403NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

objectiveTo evaluate the safety and tolerability of alternate-day fasting (ADF) and to compare changes in weight, body composition, lipids, and insulin sensitivity index (Si) with those produced by a standard weight loss diet, moderate daily caloric restriction (CR).

methodsAdults with obesity (BMI ≥30 kg/m(2) , age 18-55) were randomized to either zero-calorie ADF (n = 14) or CR (-400 kcal/day, n = 12) for 8 weeks. Outcomes were measured at the end of the 8-week intervention and after 24 weeks of unsupervised follow-up.

resultsNo adverse effects were attributed to ADF, and 93% completed the 8-week ADF protocol. At 8 weeks, ADF achieved a 376 kcal/day greater energy deficit; however, there were no significant between-group differences in change in weight (mean ± SE; ADF -8.2 ± 0.9 kg, CR -7.1 ± 1.0 kg), body composition, lipids, or Si. After 24 weeks of unsupervised follow-up, there were no significant differences in weight regain; however, changes from baseline in % fat mass and lean mass were more favorable in ADF.

conclusionsADF is a safe and tolerable approach to weight loss. ADF produced similar changes in weight, body composition, lipids, and Si at 8 weeks and did not appear to increase risk for weight regain 24 weeks after completing the intervention.

Indexed as

Caloric RestrictionFastingAdultBody CompositionBody WeightDiet, ReducingEnergy IntakeFemaleHumansMaleMiddle AgedObesityPilot ProjectsTreatment OutcomeWeight Loss

Identifiers

PMID27569118
PMCPMC5042570
OpenAlexW2518536384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.