SynthesisSleep2016
Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium.
Synthesis in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- The Interplay Between Sleep and Mental Health: A Genetic Perspective.Biological psychiatry · 2025Review
- Dissecting the genetic architecture of circadian rhythms in human tissues using a quantitative circadian deviation score.Genome biology · 2025Article
- Genomic dissection of sleep archetypes in a large autism cohort.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Estimating the True Effect of Lifestyle Risk Factors for Myopia: A Longitudinal Study of UK Children.Translational vision science & technology · 2024Article
- Genetics of sleep medication purchases suggests causality from sleep problems to psychiatric traits.Sleep · 2024Article
- Genetic correlation and causal relationship between sleep and myopia: a mendelian randomization study.Frontiers in genetics · 2024Article
- Review
- Article
- Sleep disturbances in ADHD: investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes.European child & adolescent psychiatry · 2023Article
- Genetics of circadian rhythms and sleep in human health and disease.Nature reviews. Genetics · 2023Review
- Article
- Calculating genetic risk for dysfunction in pleiotropic biological processes using whole exome sequencing data.Journal of neurodevelopmental disorders · 2022Article
- The association between bullying-victimisation and sleep disturbances in adolescence: Evidence from a twin study.Journal of sleep research · 2021Article
- Heritability of Sleep and Its Disorders in Childhood and Adolescence.Current sleep medicine reports · 2021Review
- Sleep: population epidemiology and concordance in Australian children aged 11-12 years and their parents.BMJ open · 2019Article
- Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.Nature communications · 2019Article
- The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects.European journal of epidemiology · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors.
Funding
Abstract
STUDY
objectivesLow or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits.
methodsWe performed a population-based molecular genetic study, using data form the EArly Genetics and Life course Epidemiology (EAGLE) Consortium. 10,554 children of European ancestry were included in the discovery, and 1,250 children in the replication phase.
resultsWe found evidence of significant but modest SNP heritability of sleep duration in children (SNP
conclusionsThe significant SNP heritability of sleep duration in children and the suggestive genetic overlap with type 2 diabetes support the search for genetic mechanisms linking sleep duration in children to multiple outcomes in health and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.