ArticleSleep2016
Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Periodic limb movements in Parkinson's disease: a critical review of pathophysiology and a framework for clinical management.NPJ Parkinson's disease · 2026Review
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
- Demographic Differences in Periodic Limb Movement Index and Apnea-Hypopnea Index in a Diverse Clinical Cohort.International journal of environmental research and public health · 2025Article
- Periodic leg movements and cognitive function in middle-aged and elderly adults with mediating role of REM duration and PLMS-related arousal.Scientific reports · 2025Article
- Sleep disorders after cardiac arrest: Prevalence and relation with cognitive function.Resuscitation plus · 2025Article
- Associations between longitudinal changes in sleep stages and risk of cognitive decline in older men.Sleep · 2024Article
- Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Association Between Sleep Quantity and Quality in Early Adulthood With Cognitive Function in Midlife.Neurology · 2024Article
- Sleep related movement disorders in the elderly: a review of recent literature.Frontiers in sleep · 2024Review
- Midpoint of sleep is associated with sleep quality in older adults with and without symptomatic Alzheimer's disease.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Sleep-Related Changes Prior to Cognitive Dysfunction.Current neurology and neuroscience reports · 2023Review
- High-Quality Sleep Mitigates ABCA7-Related Generalization Deficits in Healthy Older African Americans.Journal of Alzheimer's disease : JAD · 2023Article
- Zinc in Cognitive Impairment and Aging.Biomolecules · 2022Review
- Overnight Delta Dynamics Associated with Daytime Psychomotor Performance in Adults with Insomnia and Healthy Controls.Nature and science of sleep · 2022Article
- Periodic limb movements during sleep: a narrative review.Journal of thoracic disease · 2021Review
- Periodic Limb Movements Syndrome in Patients With Cerebral Small Vessel Disease: Protocol for a Prospective Observational Study.Frontiers in neurology · 2021Article
- Digital sleep measures and white matter health in the Framingham Heart Study.Exploration of medicine · 2021Article
- Specific cortical and subcortical grey matter regions are associated with insomnia severity.PloS one · 2021Article
- It's complicated: The relationship between sleep and Alzheimer's disease in humans.Neurobiology of disease · 2020Review
- Association of Sleep Electroencephalography-Based Brain Age Index With Dementia.JAMA network open · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
STUDY
objectivesTo examine the association between periodic limb movements in sleep (PLMS) and change in selected aspects of cognition in community-dwelling older men.
methodsWe studied 2,636 older men without dementia who underwent in-home polysomnography with measurement of the periodic limb movement index (PLMI) and periodic limb movement arousal index (PLMAI) using piezoelectric sensors. Random-effects models and logistic regression were used to examine the association between PLMI, PLMAI, and 3- to 4-y change in cognition.
resultsAfter multivariable adjustment, men with a high PLMI had greater decline on the Trail Making Test - Part B (P trend = 0.02); those with a PLMI ≥ 30 were 48% more likely (odds ratio = 1.48, 95% confidence interval = 1.05-2.07) to experience the development of significant cognitive impairment (≥ 1 SD above mean change). Further adjustment for sleep efficiency, nocturnal hypoxemia, or dopaminergic medication use and analysis among men without Parkinson disease (n = 2,607) showed similar findings. No significant association was found for PLMAI or for Modified Mini-Mental State Examination scores.
conclusionsAmong older men without dementia, higher PLMS frequency was associated with greater decline in cognition, particularly in executive function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.