ArticleCell reports2016
Pontomesencephalic Tegmental Afferents to VTA Non-dopamine Neurons Are Necessary for Appetitive Pavlovian Learning.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Acute fentanyl induces opposing directions of changes in tonic and phasic dopamine release patterns and impairs Pavlovian task performance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Review
- Salience Signaling and Stimulus Scaling of Ventral Tegmental Area Glutamate Neuron Subtypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release.Neuron · 2024Article
- Subregion and sex differences in ethanol activation of cholinergic and glutamatergic cells in the mesopontine tegmentum.Scientific reports · 2024Article
- Article
- Characterization of three cholinergic inputs to the cochlear nucleus.Journal of chemical neuroanatomy · 2023Article
- Neurons innervating both the central amygdala and the ventral tegmental area encode different emotional valences.Frontiers in neuroscience · 2023Article
- Behavioral Reaction andInternational journal of molecular sciences · 2022Article
- Acute MPTP Treatment Impairs Dendritic Spine Density in the Mouse Hippocampus.Brain sciences · 2021Article
- Neurobiology of reward-related learning.Neuroscience and biobehavioral reviews · 2021Review
- Microinjection of urotensin II into the pedunculopontine tegmentum leads to an increase in the consumption of sweet tastants.Physiology & behavior · 2020Article
- Dichotomy between motor and cognitive functions of midbrain cholinergic neurons.Neurobiology of disease · 2019Review
- Ventral tegmental area astrocytes orchestrate avoidance and approach behavior.Nature communications · 2019Article
- A Mini-Review of the Role of Glutamate Transporter in Drug Addiction.Frontiers in neurology · 2019Review
- Viral vector strategies for investigating midbrain dopamine circuits underlying motivated behaviors.Pharmacology, biochemistry, and behavior · 2018Review
- Minimal Circuit Model of Reward Prediction Error Computations and Effects of Nicotinic Modulations.Frontiers in neural circuits · 2018Article
- Activation of Pedunculopontine Glutamate Neurons Is Reinforcing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Commentary: Activation of Pedunculopontine Glutamate Neurons Is Reinforcing.Frontiers in behavioral neuroscience · 2017Article
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Authors and funding
8 authors.
Funding
Abstract
The ventral tegmental area (VTA) receives phenotypically distinct innervations from the pedunculopontine tegmental nucleus (PPTg). While PPTg-to-VTA inputs are thought to play a critical role in stimulus-reward learning, direct evidence linking PPTg-to-VTA phenotypically distinct inputs in the learning process remains lacking. Here, we used optogenetic approaches to investigate the functional contribution of PPTg excitatory and inhibitory inputs to the VTA in appetitive Pavlovian conditioning. We show that photoinhibition of PPTg-to-VTA cholinergic or glutamatergic inputs during cue presentation dampens the development of anticipatory approach responding to the food receptacle during the cue. Furthermore, we employed in vivo optetrode recordings to show that photoinhibition of PPTg cholinergic or glutamatergic inputs significantly decreases VTA non-dopamine (non-DA) neural activity. Consistently, photoinhibition of VTA non-DA neurons disrupts the development of cue-elicited anticipatory approach responding. Taken together, our study reveals a crucial regulatory mechanism by PPTg excitatory inputs onto VTA non-DA neurons during appetitive Pavlovian conditioning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.