ArticleNeuron2016
Virtual Cortical Resection Reveals Push-Pull Network Control Preceding Seizure Evolution.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04649008 (Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics), which is not on this map. Cited by 113 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics
Who cites it
113 citing papers in PubMed, 1 synthesis or guideline pooled it, 238 citations in OpenAlex.
- Early seizure spread and epilepsy surgery: A systematic review.Epilepsia · 2020Pooled it
- Article
- The seizure embedding map: a spatio-temporal transformer for comparing patients by ictal intracranial EEG features at scale.Journal of neural engineering · 2026Article
- Thalamocortical network dynamics in focal epilepsy: SEEG investigation.bioRxiv : the preprint server for biology · 2026Article
- sEEG-guided responsive neurostimulation to treat neocortical epilepsy: A multicenter retrospective study of the efficacy and safety of depth electrode-mediated neuromodulation.Epilepsia open · 2026Article
- White matter signals reflect information transmission between brain regions during seizures.Brain : a journal of neurology · 2026Article
- Static and dynamic intracerebral signal analysis reveals protective networks against seizures in drug-resistant focal epilepsy.Brain communications · 2026Article
- Collapse of interictal suppressive networks permits seizure spread.Brain : a journal of neurology · 2025Article
- The Seizure Embedding Map: A Spatio-Temporal Transformer for Comparing Patients by Ictal Intracranial EEG Features at Scale.medRxiv : the preprint server for health sciences · 2025Article
- Can electrical stimulation replace spontaneous seizures in epilepsy surgery?medRxiv : the preprint server for health sciences · 2025Article
- The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy.Neuroscience bulletin · 2025Review
- Neighbourhood topology unveils pathological hubs in the brain networks of epilepsy-surgery patients.Brain communications · 2025Article
- Spatial and spectral structure of local functional connectivity of the background intracranial EEG in patients with focal epilepsy.Frontiers in network physiology · 2025Article
- Single unit-derived connectivity networks in tuberous sclerosis complex reveal propensity for network hypersynchrony driven by tuber-tuber interactions.Scientific reports · 2024Article
- Virtual resection evaluation based on sEEG propagation network for drug-resistant epilepsy.Scientific reports · 2024Article
- Spontaneous Brain Activity Emerges from Pairwise Interactions in the Larval Zebrafish Brain.Physical review. X · 2024Article
- Passive and active markers of cortical excitability in epilepsy.Epilepsia · 2023Review
- Brain functional connectivity-based prediction of vagus nerve stimulation efficacy in pediatric pharmacoresistant epilepsy.CNS neuroscience & therapeutics · 2023Article
- The seizure severity score: a quantitative tool for comparing seizures and their response to therapy.Journal of neural engineering · 2023Article
- Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy.Scientific reports · 2023Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In ∼20 million people with drug-resistant epilepsy, focal seizures originating in dysfunctional brain networks will often evolve and spread to surrounding tissue, disrupting function in otherwise normal brain regions. To identify network control mechanisms that regulate seizure spread, we developed a novel tool for pinpointing brain regions that facilitate synchronization in the epileptic network. Our method measures the impact of virtually resecting putative control regions on synchronization in a validated model of the human epileptic network. By applying our technique to time-varying functional networks, we identified brain regions whose topological role is to synchronize or desynchronize the epileptic network. Our results suggest that greater antagonistic push-pull interaction between synchronizing and desynchronizing brain regions better constrains seizure spread. These methods, while applied here to epilepsy, are generalizable to other brain networks and have wide applicability in isolating and mapping functional drivers of brain dynamics in health and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.