ArticleChest2017
Obesity Is Associated With Increased Morbidity in Moderate to Severe COPD.
Article in Chest, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- BMI is associated with FEVRespiratory research · 2019Pooled it
- Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials.International journal of chronic obstructive pulmonary diseasePooled it
- Relationship between metabolically unhealthy obesity and chronic obstructive pulmonary disease among U.S. adults: Evidence from NHANES 1999-2018.Clinics (Sao Paulo, Brazil) · 2026Article
- Bidirectional Clinical Interactions among Exacerbations and Comorbidities in COPD: A Narrative Review.Seminars in respiratory and critical care medicine · 2026Review
- Exploratory Analysis of Liraglutide Effects on Obstructive Sleep Apnea and Health-Related Quality of Life in Individuals With Obesity and COPD: A Secondary Analysis of a Randomised Controlled Trial.Clinical obesity · 2026Observational
- Severe Obesity and Alpha-1 Antitrypsin Deficiency-Associated COPD: A Dual Burden on Health and Quality of Life.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations.BMC medicine · 2026Article
- GLP-1 receptor agonists and obstructive lung disease: Beyond metabolic control to respiratory outcomes.Metabolism open · 2026Review
- Targeting PLA2G7 ameliorates high-fat diet-induced pulmonary injury in obese mice, uncovering a key mechanistic link to obesity-associated COPD.Respiratory research · 2026Article
- Association Between Glucagon-Like Peptide-1 Receptor Agonists and Clinical Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Obesity.Drug design, development and therapy · 2026Article
- FGF21 Exacerbates Obesity-Induced Airway Hyperresponsiveness and FGFR1-Dependent Mast Cell Activation in Mice.Journal of inflammation research · 2026Article
- From the gut to the lungs: The role of gut microbiota in chronic obstructive pulmonary disease and related research progress.Microbial cell (Graz, Austria) · 2026Article
- Neurobeachin (NBEA) is a novel gene associated with GLP-1 receptor agonist associated weight loss.Diabetes, obesity & metabolism · 2025Article
- Association of High-Sensitivity C-Reactive Protein Levels with Proximal Airway CT Morphology in Obesity.Obesity surgery · 2025Article
- The association between adverse childhood experiences and chronic respiratory diseases in the Chinese middle-aged and elderly population.BMC public health · 2025Article
- Establishing the Obesity Paradox in Alpha-1 Antitrypsin Deficiency-Related COPD.CHEST pulmonary · 2025Article
- The association between triglyceride glucose-body mass index and mortality in critically ill patients with respiratory failure: insights from ICU data.Scientific reports · 2025Article
- The Relationship Between Anthropometric Variables and Lung Function in a Severe Smoking Community Population With Ventilatory Dysfunction.The clinical respiratory journal · 2025Article
- Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases.Nature communications · 2025Article
- Leptin and Insulin in COPD: Unveiling the Metabolic-Inflammatory Axis-A Narrative Review.Journal of clinical medicine · 2025Review
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundObesity is prevalent in the United States; however, the impact of obesity on COPD morbidity is unclear. We hypothesized that obesity is associated with worse outcomes in COPD.
methodsWe examined 3,631 participants from the multicenter prospective cohort study Genetic Epidemiology of COPD (COPDGene) who had spirometry-confirmed COPD, a postbronchodilator FEV
resultsOverall, 35% of participants were obese, with 21% class I (BMI range, 30-34.9 kg/m
conclusionsObesity is prevalent among individuals with COPD and associated with worse COPD-related outcomes, ranging from QOL and dyspnea to 6MWD and severe AECOPD. These associations were strengthened when obesity was analyzed as a dose-dependent response. Obesity in patients with COPD may contribute to a worse COPD-related course.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.