Trial reportArchives of physical medicine and rehabilitation2017
Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study.
Trial report in Archives of physical medicine and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Vitamin D supplementation and exercise for improving physical function, body composition and metabolic health in overweight or obese older adults with vitamin D deficiency: a pilot randomized, double-blind, placebo-controlled trial.European journal of nutrition · 2023Trial
- Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial.Alzheimer's research & therapy · 2020Trial
- Poorer Physical Function Is Associated With Elevated Spatial Entropy in the Aging Brain Network Landscape.Aging cell · 2026Article
- Dysfunction in Olfactory Identification and Physical Function Decline in Older Adults.JAMA otolaryngology-- head & neck surgery · 2026Article
- Frailty Matters: Validation of an Automated Electronic Short Physical Performance Battery (eSPPB) for Predicting 30-Day Mortality in Hospitalized Cardiovascular Patients-A Step-by-Step Study.Journal of clinical medicine · 2026Article
- Reporting randomised trials of physical exercise or training interventions in older adults: the PETIO guideline.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Relationship Between Accelerated Biological Aging, Race, Perceived Discrimination, and Limitations in Activities of Daily Living.International journal of geriatrics and gerontology · 2025Article
- Enhancing Minds in Motion® as a virtual program delivery model for people living with dementia and their care partners.PloS one · 2024Article
- Review
- Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary.GeroScience · 2023Review
- Symptom Profiles, Health-Related Quality of Life, and Clinical Blood Markers among Korean Community-Dwelling Older Adults Living with Chronic Conditions.International journal of environmental research and public health · 2021Article
- Integrating a Prevention Care Path into the Daily Life of Older Adults with Mobility Disability Risk: Introducing a Predictive Response Model to Exercise.Clinical interventions in aging · 2021Article
- Trajectories of Short Physical Performance Battery Are Strongly Associated with Future Major Mobility Disability: Results from the LIFE Study.Journal of clinical medicine · 2020Article
- Prevalence and factors associated with physical function limitation in older West African people living with HIV.PloS one · 2020Article
- Age-Related Improvements in Peak Cardiorespiratory Fitness among Coronary Heart Disease Patients Following Cardiac Rehabilitation.Journal of clinical medicine · 2019Article
- Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial.Journal of clinical medicine · 2019Article
- Effects of hindlimb suspension and reloading on gastrocnemius and soleus muscle mass and function in geriatric mice.Experimental gerontology · 2019Article
- Stepping Up to Rethink the Future of Rehabilitation: IV STEP Considerations and Inspirations.Journal of neurologic physical therapy : JNPT · 2017Article
- Stepping Up to Rethink the Future of Rehabilitation: IV STEP Considerations and Inspirations.Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association · 2017Article
- Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial.Contemporary clinical trials communications · 2017Article
Corrections and comments
- Commented on by
- Erratum issuedCorrection.2017
Authors and funding
15 authors at 9 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability.
designSecondary analysis.
settingMulticenter institutions.
participantsA volunteer sample (N=1635) of sedentary men and women aged 70 to 89 years who were able to walk 400m but had physical limitations, defined as a Short Physical Performance Battery (SPPB) score of ≤9.
interventionsModerate-intensity physical activity (n=818) consisting of aerobic, resistance, and flexibility exercises performed both center-based (2times/wk) and home-based (3-4times/wk) sessions or health education program (n=817) consisting of weekly to monthly workshops covering relevant health information.
main outcome measuresPhysical function (gait speed over 400m) and lower extremity function (SPPB score) assessed at baseline and 6, 12, and 24 months.
resultsGreater baseline physical function (gait speed, SPPB score) was negatively associated with change in gait speed (regression coefficient β=-.185; P<.001) and change in SPPB score (β=-.365; P<.001), whereas higher number of steps per day measured by accelerometry was positively associated with change in gait speed (β=.035; P<.001) and change in SPPB score (β=.525; P<.001). Other baseline factors associated with positive change in gait speed and/or SPPB score include younger age (P<.001), lower body mass index (P<.001), and higher self-reported physical activity (P=.002).
conclusionsSeveral demographic and physical activity-related factors were associated with the extent of change in functional outcomes in participants in the LIFE study. These factors should be considered when designing interventions for improving physical function in older adults with limited mobility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.