Evidence map›Paper›PMID 27567968›Full record

ArticleDrug and alcohol dependence2016

The role of alcohol use in antiretroviral adherence among individuals living with HIV in South Africa: Event-level findings from a daily diary study.

Katelyn M Sileo, Leickness C Simbayi, Amber Abrams, Allanise Cloete, Susan M Kiene

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  11. PromotingInternational journal of environmental research and public health · 2020
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  20. Alcohol Use and HIV Disease Progression in an Antiretroviral Naive Cohort.Journal of acquired immune deficiency syndromes (1999) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katelyn M SileoDivision of Epidemiology and Biostatistics, Graduate School of Public Health, San Diego State University, San Diego, CA, United States.
Leickness C SimbayiHuman Sciences Research Council, Cape Town, South Africa; Department of Psychiatry & Mental Health, University of Cape Town, South Africa.
Amber AbramsCochrane South Africa, South African Medical Research Council, School of Anthropology and Conservation, University of Kent, South Africa.
Allanise CloeteHuman Sciences Research Council, Cape Town, South Africa.
Susan M KieneDivision of Epidemiology and Biostatistics, Graduate School of Public Health, San Diego State University, San Diego, CA, United States. Electronic address: skiene@mail.sdsu.edu.

Funding

Training Program in Substance Use, HIV and Related InfectionsT32DA023356 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Natasha Martin, Steffanie A Strathdee · 2007 to 2026
$7.8M
Dynamics of HIV Risk Behavior: A Daily Process ApproachF31MH072547 · NIMH · UNIVERSITY OF CONNECTICUT STORRS · PI KIENE, SUSAN MARIA · 2004 to 2006
$91k
NIDA NIH HHS T32 DA023356NIMH NIH HHS F31 MH072547
6 · The paper itself

Abstract

objectiveUsing daily diary methods, we aimed to test the hypothesis that at the event-level consuming alcohol increases the likelihood that antiretrovirals (ARV) will be missed on a particular day.

methodsThis prospective cohort study of 74 (52 female, 22 male) people living with HIV (PLHIV) in South Africa collected event-level data on ARV adherence and alcohol consumption using structured daily phone interviews over a period of 42days generating 2718 data points. We used generalized estimating equations (GEE) analyses to assess univariate and multivariate associations between alcohol and adherence, controlling for sociodemographics and testing for effect modification.

resultsControlling for sociodemographics, each alcohol measure was a statistically significant predictor of non-adherence on a particular day; any drinking compared to no drinking (daytime: AOR=3.18, 95% CI=2.25-4.49; evening: AOR=3.43, 95% CI=2.12-5.53), consuming more alcohol than one normally consumes (daytime: AOR=1.06, 95% CI=1.02-1.11; evening: AOR=1.10, 95% CI=1.05-1.15), and drinking at low to moderate risk level (daytime: 4.29, 95% CI=2.81-6.56; evening: AOR=4.24, 95% CI=2.38-7.54) and high to very high risk levels (daytime: AOR=2.31, 95% CI=1.56-3.42; evening: AOR=3.08, 95% CI=1.91-4.98) were all significantly related to missing ARVs in the daytime and evening.

conclusionsThese data provide support for an event-level relationship between alcohol and non-adherence. Interventions that mitigate alcohol use among people on ARVs or provide strategies to maintain optimal adherence among those who drink are needed.

Indexed as

AdultAlcohol DrinkingAnti-Retroviral AgentsFemaleHIV InfectionsHumansMaleMedication AdherenceMiddle AgedProspective StudiesSouth AfricaYoung AdultAnti-Retroviral AgentsAdherenceAlcoholARTEvent-level analysisHIV/AIDSSouth Africa

Identifiers

PMID27567968
PMCPMC5037036

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.