ArticleJournal of Alzheimer's disease : JAD2016
Staging Alzheimer's Disease Risk by Sequencing Brain Function and Structure, Cerebrospinal Fluid, and Cognition Biomarkers.
Article in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Stage-Aware Event-Based Modeling (SA-EBM) for Disease Progression.Proceedings of machine learning research · 2025Article
- Distinct Functional Connectivity Patterns for Intermittent Vs Constant Neuropathic Pain Phenotypes in Persistent Spinal Pain Syndrome Type 2 Patients.Journal of pain research · 2024Article
- PICALM rs3851179 Variants Modulate Left Postcentral Cortex Thickness, CSF Amyloid β42, and Phosphorylated Tau in the Elderly.Brain sciences · 2022Article
- Imminent cognitive decline in normal elderly individuals is associated with hippocampal hyperconnectivity in the variant neural correlates of episodic memory.European archives of psychiatry and clinical neuroscience · 2022Article
- Comparison and aggregation of event sequences across ten cohorts to describe the consensus biomarker evolution in Alzheimer's disease.Alzheimer's research & therapy · 2022Article
- Disease Modelling of Cognitive Outcomes and Biomarkers in the European Prevention of Alzheimer's Dementia Longitudinal Cohort.Frontiers in big data · 2021Review
- tDCS-Induced Memory Reconsolidation Effects and Its Associations With Structural and Functional MRI Substrates in Subjective Cognitive Decline.Frontiers in aging neuroscience · 2021Article
- Multiple Connection Pattern Combination From Single-Mode Data for Mild Cognitive Impairment Identification.Frontiers in cell and developmental biology · 2021Article
- A social dancing pilot intervention for older adults at high risk for Alzheimer's disease and related dementias.Neurodegenerative disease management · 2020Article
- Predicting conversion to Alzheimer's disease among individual high-risk patients using the Characterizing AD Risk Events index model.CNS neuroscience & therapeutics · 2020Article
- Sequences of cognitive decline in typical Alzheimer's disease and posterior cortical atrophy estimated using a novel event-based model of disease progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- The Role of Resting-State Network Functional Connectivity in Cognitive Aging.Frontiers in aging neuroscience · 2020Article
- Functional connectivity and structural analysis of trial spinal cord stimulation responders in failed back surgery syndrome.PloS one · 2020Article
- Reduced Dynamic Complexity of BOLD Signals Differentiates Mild Cognitive Impairment From Normal Aging.Frontiers in aging neuroscience · 2020Article
- Article
- Differential tDCS and tACS Effects on Working Memory-Related Neural Activity and Resting-State Connectivity.Frontiers in neuroscience · 2019Article
- Challenges of Integrative Disease Modeling in Alzheimer's Disease.Frontiers in molecular biosciences · 2019Review
- A Pilot Study Investigating a Novel Non-Linear Measure of Eyes Open versus Eyes Closed EEG Synchronization in People with Alzheimer’s Disease and Healthy ControlsBrain sciences · 2018Article
- Mitochondria and Mitochondrial Cascades in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2018Review
- β-Amyloid and the Pathomechanisms of Alzheimer's Disease: A Comprehensive View.Molecules (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
This study aims to develop a composite biomarker that can accurately measure the sequential biological stages of Alzheimer's disease (AD) on an individual level. We selected 144 subjects from the Alzheimer's Disease Neuroimaging Initiative 2 datasets. Ten biomarkers, from brain function and structure, cerebrospinal fluid, and cognitive performance, were integrated using the event-based probabilistic model to estimate their optimal temporal sequence (Soptimal). We identified the numerical order of the Soptimal as the characterizing Alzheimer's disease risk events (CARE) index to measure disease stage. The results show that, in the Soptimal, hippocampal and posterior cingulate cortex network biomarkers occur first, followed by aberrant cerebrospinal fluid amyloid-β and p-tau levels, then cognitive deficit, and finally regional gray matter loss and fusiform network abnormality. The CARE index significantly correlates with disease severity and exhibits high reliability. Our findings demonstrate that use of the CARE index would advance AD stage measurement across the whole AD continuum and facilitate personalized treatment of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.