Evidence map›Paper›PMID 27567871›Full record

ReviewJournal of Alzheimer's disease : JAD2016

Stroke, Vascular Dementia, and Alzheimer's Disease: Molecular Links.

Murali Vijayan, P Hemachandra Reddy

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04560296 (Community-based E-Health Program for Older Adults Living With Chronic Diseases - A Cluster Controlled Study With Process Evaluation), which is not on this map. Cited by 134 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 3 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04560296 nacompletednot on this mapstarted 2020, after this paper: background citation

Community-based E-Health Program for Older Adults Living With Chronic Diseases - A Cluster Controlled Study With Process Evaluation

TypeinterventionalSponsorNational University of SingaporeRan2020 to 2024Enrolled150ConditionsDiabetes Mellitus, Hypertension, HyperlipidemiasArmsCommunity-based E-Health Program, usual self-management and follow up with doctors/nurse
3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 3 syntheses or guidelines pooled it, 259 citations in OpenAlex.

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74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Murali VijayanGarrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
P Hemachandra ReddyGarrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Texas Tech University · US

Funding

Dynamin-Related Protein 1 and Mitochondrial Fragmentation in Alzheimer's DiseaseR01AG042178 · NIA · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI REDDY, P. HEMACHANDRA · 2012 to 2016
$2.0M
Voltage-Dependent Anion Channel and Neurodegeneration in Alzheimer's DiseaseR01AG047812 · NIA · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI REDDY, P. HEMACHANDRA · 2014 to 2018
$1.9M
NIA NIH HHS R01 AG042178NIA NIH HHS R01 AG047812
6 · The paper itself

Abstract

Stroke is a brain disease that occurs when blood flow stops, resulting in reduced oxygen supply to neurons. Stroke occurs at any time and at any age, but increases after the age of 55. It is the second leading cause of death and the third leading cause of disability-adjusted, life-years. The pathophysiology of ischemic stroke is complex and recent molecular, cellular, and animal models and postmortem brain studies have revealed that multiple cellular changes have been implicated, including oxidative stress/mitochondrial dysfunction, inflammatory responses, micro RNA alterations, and marked changes in brain proteins. These cellular changes provide new information for developing therapeutic strategies for ischemic stroke treatment. Research also revealed that stroke increases with a number of modifiable factors and most strokes can be prevented and/or controlled through pharmacological or surgical interventions and lifestyle changes. Ischemic stroke is the major risk factor for vascular dementia and Alzheimer's disease. This review summarizes the latest research findings on stroke, including causal factors and molecular links between stroke and vascular disease/Alzheimer's disease.

Indexed as

Alzheimer DiseaseAmine Oxidase (Copper-Containing)AnimalsCell Adhesion MoleculesDementia, VascularDiabetes MellitusHumansInflammation MediatorsNitric Oxide Synthase Type IIRisk FactorsSmokingStrokeAmine Oxidase (Copper-Containing)AOC3 protein, humanCell Adhesion MoleculesInflammation MediatorsNitric Oxide Synthase Type IINOS2 protein, humanAlzheimer’s diseasehemorrhageinflammatory responsesischemic strokemagnetic resonance imagingvascular dementia

Identifiers

PMID27567871
PMCPMC5793908
OpenAlexW2516368667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.