ArticleMolecular and cellular neurosciences2016
Presynaptic CamKII regulates activity-dependent axon terminal growth.
Article in Molecular and cellular neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- ATP synthase subunits e and g are essential for CaCell death and differentiation · 2026Article
- Local Synthesis of CaMKII Does Not Contribute to Activity-Dependent Generation of Ghost Boutons.eNeuro · 2026Article
- CaMKII as a Multimodal Signalling Hub in Neural Connectivity and Vulnerability.Molecular neurobiology · 2026Review
- Regulation of miR-219 and its target RalGPS dictates acute synaptic plasticity at thebioRxiv : the preprint server for biology · 2025Article
- Activity drives local CaMKII synthesis and subcellular localization via autophosphorylation-dependent pathways.bioRxiv : the preprint server for biology · 2025Article
- Degradation of CaMKII is stimulated by its active conformation.The Journal of biological chemistry · 2025Article
- Axon termination of the SAB motor neurons inbioRxiv : the preprint server for biology · 2025Article
- Skewing information flow through pre- and postsynaptic plasticity in the mushroom bodies ofLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- TheFrontiers in synaptic neuroscience · 2024Article
- Age-related ceRNA networks in adultFrontiers in genetics · 2023Article
- Local translation provides the asymmetric distribution of CaMKII required for associative memory formation.Current biology : CB · 2022Article
- Role of CaFrontiers in molecular neuroscience · 2022Review
- Review
- Axonal mRNA translation in neurological disorders.RNA biology · 2021Review
- Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain.eLife · 2021Article
- A comparison of three different methods of eliciting rapid activity-dependent synaptic plasticity at the Drosophila NMJ.PloS one · 2021Article
- Vps54 regulatesBiology open · 2020Article
- CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles.PLoS biology · 2020Article
- FMRFa receptor stimulated Ca2+ signals alter the activity of flight modulating central dopaminergic neurons in Drosophila melanogaster.PLoS genetics · 2018Article
- The Long 3'UTR mRNA ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Spaced synaptic depolarization induces rapid axon terminal growth and the formation of new synaptic boutons at the Drosophila larval neuromuscular junction (NMJ). Here, we identify a novel presynaptic function for the Calcium/Calmodulin-dependent Kinase II (CamKII) protein in the control of activity-dependent synaptic growth. Consistent with this function, we find that both total and phosphorylated CamKII (p-CamKII) are enriched in axon terminals. Interestingly, p-CamKII appears to be enriched at the presynaptic axon terminal membrane. Moreover, levels of total CamKII protein within presynaptic boutons globally increase within one hour following stimulation. These effects correlate with the activity-dependent formation of new presynaptic boutons. The increase in presynaptic CamKII levels is inhibited by treatment with cyclohexamide suggesting a protein-synthesis dependent mechanism. We have previously found that acute spaced stimulation rapidly downregulates levels of neuronal microRNAs (miRNAs) that are required for the control of activity-dependent axon terminal growth at this synapse. The rapid activity-dependent accumulation of CamKII protein within axon terminals is inhibited by overexpression of activity-regulated miR-289 in motor neurons. Experiments in vitro using a CamKII translational reporter show that miR-289 can directly repress the translation of CamKII via a sequence motif found within the CamKII 3' untranslated region (UTR). Collectively, our studies support the idea that presynaptic CamKII acts downstream of synaptic stimulation and the miRNA pathway to control rapid activity-dependent changes in synapse structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.