Evidence map›Paper›PMID 27567615›Full record

ArticleLa Radiologia medica2016

Magnetic resonance-guided focused ultrasound for the treatment of painful bone metastases: role of apparent diffusion coefficient (ADC) and dynamic contrast enhanced (DCE) MRI in the assessment of clinical outcome.

Michele Anzidei, Alessandro Napoli, Beatrice Sacconi, Fabrizio Boni, Vincenzo Noce, Michele Di Martino, Luca Saba, Carlo Catalano

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in La Radiologia medica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03404362 (A Two-center Phase II, Non-randomized Study of MRgFUS Versus EBRT in Patients With Metastatic Non-spinal Bone Disease), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03404362 nacompletednot on this mapstarted 2017, after this paper: background citation

A Two-center Phase II, Non-randomized Study of MRgFUS Versus EBRT in Patients With Metastatic Non-spinal Bone Disease: Palliative Strategy for Cancer-Induced Bone Pain

TypeinterventionalSponsorUniversity of Roma La SapienzaRan2017 to 2020Enrolled198ConditionsSecondary Bone Cancer, Bone MetastasesArmsBone Metastases Pain treatment
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michele AnzideiDepartment of Radiological, Oncological and Anatomopathological Sciences, Radiology, "Sapienza" University of Rome, Viale Regina Elena 324, 00161, Rome, Italy. michele.anzidei@gmail.com.
Alessandro NapoliDepartment of Radiological, Oncological and Anatomopathological Sciences, Radiology, "Sapienza" University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Beatrice SacconiDepartment of Radiological, Oncological and Anatomopathological Sciences, Radiology, "Sapienza" University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Fabrizio BoniDepartment of Radiological, Oncological and Anatomopathological Sciences, Radiology, "Sapienza" University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Vincenzo NoceDepartment of Radiological, Oncological and Anatomopathological Sciences, Radiology, "Sapienza" University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Michele Di MartinoDepartment of Radiological, Oncological and Anatomopathological Sciences, Radiology, "Sapienza" University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Luca SabaDepartment of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari, Polo di Monserrato, Cagliari, Italy.
Carlo CatalanoDepartment of Radiological, Oncological and Anatomopathological Sciences, Radiology, "Sapienza" University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the correlation between functional MRI, including ADC values obtained from DWI and DCE, and clinical outcome in patients with bone metastases treated with MRgFUS. METHODS AND MATERIALS: Twenty-three patients with symptomatic bone metastases underwent MRgFUS treatment (ExAblate 2100 system InSightec) for pain palliation. All patients underwent clinical and imaging follow-up examinations at 1, 3 and 6 months after treatment. Visual Analog Scale (VAS) score was used to evaluate treatment efficacy in terms of pain palliation while ADC maps obtained by DWI sequences, and DCE data were used for quantitative assessment of treatment response at imaging. Spearman Correlation Coefficient Test was calculated to assess the correlation between VAS, ADC and DCE data.

resultsAll treatments were performed successfully without adverse events. On the basis of VAS score, 16 (69.6 %) patients were classified as complete clinical responders, 6 (26.1 %) as partial responders and only one (4.3 %) was classified as a non-responder. The mean VAS score decreased from 7.09 ± 1.8 at baseline to 2.65 ± 1.36 at 1 month, 1.04 ± 1.91 at 3 months and 1.09 ± 1.99 at 6 months (p < 0.001). Baseline mean ADC value of treated lesions was 1.05 ± 0.15 mm

conclusionIn patients with painful bone metastases treated with MRgFUS, ADC and Ktrans variation observed in the ablated lesions correlate with VAS values and may play a role as objective imaging marker of treatment response.

Indexed as

High-Intensity Focused Ultrasound AblationSurgery, Computer-AssistedAdultAgedAged, 80 and overBone NeoplasmsContrast MediaDiffusion Magnetic Resonance ImagingFemaleHumansLife ExpectancyMagnetic Resonance ImagingMagnetic Resonance Imaging, InterventionalMaleMiddle AgedPain ManagementContrast MediaADCApparent diffusion coefficientBone metastasesDCEDiffusion-weighted imagingDWIDynamic contrast enhanced MRIMRgFUSMR-guided Focused Ultrasound

Identifiers

PMID27567615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.