Evidence map›Paper›PMID 27567607›Full record

ArticleAbdominal radiology (New York)2017

Diffusion-weighted imaging for evaluating inflammatory activity in Crohn's disease: comparison with histopathology, conventional MRI activity scores, and faecal calprotectin.

D A Pendsé, J C Makanyanga, A A Plumb, G Bhatnagar, D Atkinson, Manuel Rodriguez-Justo, S Halligan, S A Taylor

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Abdominal radiology (New York), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

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  13. Association Between Level of Fecal Calprotectin and Progression of Crohn's Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

D A PendséUniversity College London Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0002-6326-4658
J C MakanyangaUniversity College London Hospitals NHS Foundation Trust, London, UK.
A A PlumbUniversity College London Hospitals NHS Foundation Trust, London, UK.
G BhatnagarUniversity College London Hospitals NHS Foundation Trust, London, UK.
D AtkinsonUniversity College London Hospitals NHS Foundation Trust, London, UK.
Manuel Rodriguez-JustoUniversity College London Hospitals NHS Foundation Trust, London, UK.
S HalliganUniversity College London Hospitals NHS Foundation Trust, London, UK.
S A TaylorUniversity College London Hospitals NHS Foundation Trust, London, UK. stuart.taylor@uclh.nhs.uk.
University College London Hospitals NHS Foundation Trust · GBUniversity College Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate whether the extent of enteric diffusion-weighted imaging (DWI) signal abnormality reflects inflammatory burden in Crohn's disease (CD), and to compare qualitative and quantitative grading.

methods69 CD patients (35 male, age 16-78) undergoing MR enterography with DWI (MRE-D) and the same-day faecal calprotectin (cohort 1) were supplemented by 29 patients (19 male, age 16-70) undergoing MRE-D and terminal ileal biopsy (cohort 2). Global (cohort 1) and terminal ileal (cohort 2) DWI signal was graded (0 to 3) by 2 radiologists and segmental apparent diffusion coefficient (ADC) calculated. Data were compared to calprotectin and a validated MRI activity score [MEGS] (cohort 1), and a histopathological activity score (eAIS) (cohort 2) using nonparametric testing and rank correlation.

resultsPatients with normal (grades 0 and 1) DWI signal had lower calprotectin and MEGS than those with abnormal signal (grades 2 and 3) (160 vs. 492 μg/l, p = 0.0004, and 3.3 vs. 21, p < 0.0001), respectively. Calprotectin was lower if abnormal DWI affected <10 cm of small bowel compared to diffuse small and large bowel abnormality (236 vs. 571 μg, p = 0.009). The sensitivity and specificity for active disease (calprotectin > 120 μg/l) were 83% and 52%, respectively. There was a negative correlation between ileal MEGS and ADC (r = -0.41, p = 0.017). There was no significant difference in eAIS between qualitative DWI scores (p = 0.42). Mean ADC was not different in those with and without histological inflammation (2077 vs. 1622 × 10

Indexed as

AdolescentAdultAgedBiomarkers, TumorBiopsyCrohn DiseaseDiffusion Magnetic Resonance ImagingFecesFemaleHumansLeukocyte L1 Antigen ComplexMagnetic Resonance ImagingMaleMiddle AgedSensitivity and SpecificityBiomarkers, TumorLeukocyte L1 Antigen ComplexCrohns diseaseDiffusionImagingInflammatory bowel disease (IBD)Magnetic resonance imaging (MRI)

Identifiers

PMID27567607
PMCPMC5243884
OpenAlexW2507217925

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.