ArticleBMC complementary and alternative medicine2016
The association between arterial stiffness and tongue manifestations of blood stasis in patients with type 2 diabetes.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- A dynamic weighted ensemble learning framework for cardiovascular risk prediction in type 2 diabetes: a comparative study with SHAP-based interpretability.Scientific reports · 2025Article
- Perspectives on tongue coating: etiology, clinical management, and associated diseases - a narrative review.The Saudi dental journal · 2025Review
- An improved lightweight tongue segmentation model with self-attention parallel network and progressive upsampling.Scientific reports · 2025Article
- Diabetic peripheral neuropathy detection of type 2 diabetes using machine learning from TCM features: a cross-sectional study.BMC medical informatics and decision making · 2025Observational
- Retroflex tongue as a non-invasive neurological marker of functional severity in older adults with ischemic stroke: a retrospective observational study.Frontiers in neurology · 2025Article
- Using Advanced Convolutional Neural Network Approaches to Reveal Patient Age, Gender, and Weight Based on Tongue Images.BioMed research international · 2024Article
- Exploring the pivotal variables of tongue diagnosis between patients with chronic kidney disease and health participants.Frontiers in big data · 2024Article
- Dark red tongue color formation caused by hyperglycemia is attributed to decreased blood flow of tongue tissue partially due to nuclear factor-kappa B pathway activation.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Article
- Formulation and Interpretation of International Diagnostic Guidelines for Blood-Stasis Syndrome.Chinese journal of integrative medicine · 2022Article
- Panoramic tongue imaging and deep convolutional machine learning model for diabetes diagnosis in humans.Scientific reports · 2022Article
- Machine Learning-Based Technique for the Severity Classification of Sublingual Varices according to Traditional Chinese Medicine.Computational and mathematical methods in medicine · 2022Article
- Deep Learning Multi-label Tongue Image Analysis and Its Application in a Population Undergoing Routine Medical Checkup.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Tongue image quality assessment based on a deep convolutional neural network.BMC medical informatics and decision making · 2021Article
- Can Traditional Chinese Medicine Diagnosis Be Parameterized and Standardized? A Narrative Review.Healthcare (Basel, Switzerland) · 2021Review
- A Perspective on Tongue Diagnosis in Patients with Breast Cancer.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Article
- Observational
- Infrared Thermal Imaging for Diabetes Detection and Measurement.Journal of medical systems · 2019Article
- Tongue diagnosis indices for upper gastrointestinal disorders: Protocol for a cross-sectional, case-controlled observational study.Medicine · 2018Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus (DM) is a hypercoagulable state and is associated with highly increased risk of vascular complications. In the theory of traditional Chinese medicine (TCM), these vascular complications are classified as blood stasis. Diagnosis of the tongue plays an important role in TCM; a bluish tongue, petechiae, and engorged sublingual collateral vessels are manifestations of blood stasis. This study aimed to characterize the tongue manifestations of blood stasis and derive a relationship between blood stasis and vascular disorders in patients with type 2 DM.
methodWe conducted a cross-sectional study of 140 patients with type 2 DM, and compared demography, laboratory, physical examination, ankle brachial index(ABI), brachial-ankle pulse wave velocity (ba-PWV), and tongue manifestation datas. An automatic tongue diagnosis system was used to capture tongue images and characterize clinical tongue manifestations.
resultsA bluish or petechiae tongue was assoicated with a significant decrease in high-density lipoprotein level, and bluish tongue was associated with significant increase in blood triglyceride in patients with type 2 DM. On assessing arterial stiffness, patients with a petechiae tongue had a higher ba-PWV for both sides (L:1938.41 ± 469.54 cm/sec v.s.1723.99 ± 302.16, p = 0.02; R:1937.28 ± 405.55 v.s.1741.99 ± 325.82, p = 0.03).
conclusionBlood stasis, particularly a tongue with petechiae, may be associated with arterial stiffness in patients with type 2 DM. Furthermore, tongue diagnosis could detect blood stasis relevant to DM and could serve as a feasible predictor for DM.
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