ArticleBiological psychiatry2017
Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene.
Article in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 94 citations in OpenAlex.
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- Long-read whole-genome sequencing of SHR rat substrains with distinct substance use phenotypes.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Excess Neonatal Testosterone Causes Male-Specific Social and Fear Memory Deficits in Wild-Type Mice.eNeuro · 2025Article
- Sleep and circadian disturbances in children with neurodevelopmental disorders.Nature reviews. Neurology · 2025Review
- Altered socio-affective communication and amygdala development in mice with protocadherin10-deficient interneurons.Open biology · 2024Article
- Mutations associated with autism lead to similar synaptic and behavioral alterations in both sexes of male and female mouse brain.Scientific reports · 2024Article
- miR-218-5p and miR-320a-5p as Biomarkers for Brain Disorders: Focus on the Major Depressive Disorder and Parkinson's Disease.Molecular neurobiology · 2023Article
- Sociability versus empathy in adolescent mice: Different or distinctive?Learning and motivation · 2023Article
- The role of Pcdh10 in neurological disease and cancer.Journal of cancer research and clinical oncology · 2023Review
- Article
- Genetic and neural mechanisms of sleep disorders in children with autism spectrum disorder: a review.Frontiers in psychiatry · 2023Review
- ASD/OCD-Linked Protocadherin-10 Regulates Synapse, But Not Axon, Development in the Amygdala and Contributes to Fear- and Anxiety-Related Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- A chromosome-scale genome assembly of the false clownfish, Amphiprion ocellaris.G3 (Bethesda, Md.) · 2022Article
- Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms.BMC cancer · 2022Article
- Krüppel-like Transcription Factor 7 Is a Causal Gene in Autism Development.International journal of molecular sciences · 2022Article
- Control of Behavioral Arousal and Defense by a Glutamatergic Midbrain-Amygdala Pathway in Mice.Frontiers in neuroscience · 2022Article
- Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes.Scientific reports · 2021Article
- Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors.Communications biology · 2021Article
- The γ-Protocadherins Interact Physically and Functionally with Neuroligin-2 to Negatively Regulate Inhibitory Synapse Density and Are Required for Normal Social Interaction.Molecular neurobiology · 2021Article
- Age- and sex-specific fear conditioning deficits in mice lacking Pcdh10, an Autism Associated Gene.Neurobiology of learning and memory · 2021Article
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Authors and funding
21 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundBehavioral symptoms in individuals with autism spectrum disorder (ASD) have been attributed to abnormal neuronal connectivity, but the molecular bases of these behavioral and brain phenotypes are largely unknown. Human genetic studies have implicated PCDH10, a member of the δ2 subfamily of nonclustered protocadherin genes, in ASD. PCDH10 expression is enriched in the basolateral amygdala, a brain region implicated in the social deficits of ASD. Previous reports indicate that Pcdh10 plays a role in axon outgrowth and glutamatergic synapse elimination, but its roles in social behaviors and amygdala neuronal connectivity are unknown. We hypothesized that haploinsufficiency of Pcdh10 would reduce social approach behavior and alter the structure and function of amygdala circuits.
methodsMice lacking one copy of Pcdh10 (Pcdh10
resultsMale Pcdh10
conclusionsOur studies reveal that male Pcdh10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.