ArticleUrologic oncology2017
Tumor contact with prostate capsule on magnetic resonance imaging: A potential biomarker for staging and prognosis.
Article in Urologic oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- 10 mm (PI-RADS v2.1) versus 15 mm (PI-RADS v1.0) tumor capsule contact length in predicting extracapsular extension in prostate cancer: Meta-analysis and systematic review.Abdominal radiology (New York) · 2025Pooled it
- The Role of Magnetic Resonance Imaging and Positron Emission Tomography/Computed Tomography in the Primary Staging of Newly Diagnosed Prostate Cancer: A Systematic Review of the Literature.European urology oncology · 2021Pooled it
- The Quantitative Assessment of Using Multiparametric MRI for Prediction of Extraprostatic Extension in Patients Undergoing Radical Prostatectomy: AFrontiers in oncology · 2021Pooled it
- The Diagnostic Performance of the Length of Tumor Capsular Contact on MRI for Detecting Prostate Cancer Extraprostatic Extension: A Systematic Review and Meta-Analysis.Korean journal of radiology · 2020Pooled it
- Article
- Quantitative magnetic resonance imaging in prostate cancer: A review of current technology.World journal of radiology · 2024Review
- Defining the role of multiparametric MRI in predicting prostate cancer extracapsular extension.World journal of urology · 2024Article
- Amide proton transfer imaging has added value for predicting extraprostatic extension in prostate cancer patients.Frontiers in oncology · 2024Article
- Article
- Negative mpMRI Rules Out Extra-Prostatic Extension in Prostate Cancer before Robot-Assisted Radical Prostatectomy.Diagnostics (Basel, Switzerland) · 2022Article
- Quantitative imaging parameters to predict the local staging of prostate cancer in intermediate- to high-risk patients.Insights into imaging · 2022Article
- The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimensTurkish journal of medical sciences · 2021Article
- MRI detected extaprostatic extension (EPE) in prostate cancer: Do all T3a patients have the same outcomes?Clinical and translational radiation oncology · 2020Article
- Assessing Extraprostatic Extension with Multiparametric MRI of the Prostate: Mehralivand Extraprostatic Extension Grade or Extraprostatic Extension Likert Scale?Radiology. Imaging cancer · 2020Article
- Prediction of extraprostatic extension by MRI tumor contact length: difference between anterior and posterior prostate cancer.Prostate cancer and prostatic diseases · 2019Article
- Index tumor volume on MRI as a predictor of clinical and pathologic outcomes following radical prostatectomy.International urology and nephrology · 2019Article
- Apparent diffusion coefficient in extraprostatic extension of prostate cancer: a systematic review and diagnostic meta-analysis.Cancer management and research · 2019Article
- Prospective comparison of PI-RADS version 2 and qualitative in-house categorization system in detection of prostate cancer.Journal of magnetic resonance imaging : JMRI · 2018Article
- Validation of PI-RADS Version 2 in Transition Zone Lesions for the Detection of Prostate Cancer.Radiology · 2018Article
- Pathological and 3 Tesla Volumetric Magnetic Resonance Imaging Predictors of Biochemical Recurrence after Robotic Assisted Radical Prostatectomy: Correlation with Whole Mount Histopathology.The Journal of urology · 2018Observational
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundThe high-spatial resolution of multiparametric magnetic resonance imaging (mpMRI) has improved the detection of clinically significant prostate cancer. mpMRI characteristics (extraprostatic extension [EPE], number of lesions, etc.) may predict final pathological findings (positive lymph node [pLN] and pathological ECE [pECE]) and biochemical recurrence (BCR). Tumor contact length (TCL) on MRI, defined as the length of a lesion in contact with the prostatic capsule, is a novel marker with promising early results. We aimed to evaluate TCL as a predictor of +pathological EPE (+pEPE),+pathological LN (+pLN), and BCR in patients undergoing robotic-assisted laparoscopic radical prostatectomy. MATERIALS AND
methodsA review was performed of a prospectively maintained single-institution database of men with prostate cancer who underwent prostate mpMRI followed by robotic-assisted laparoscopic radical prostatectomy without prior therapy from 2007 to 2015. TCL was measured using T2-weighted magnetic resonance images. Logistic and Cox regression analysis were used to assess associations of clinical, imaging, and histopathological variables with pEPE, pLN, and BCR. Receiver operating characteristic curves were used to characterize and compare TCL performance with Partin tables.
resultsThere were 87/379 (23.0%)+pEPE, 18/384 (4.7%)+pLN, and 33/371 (8.9%) BCR patients. Patients with adverse pathology/oncologic outcomes had longer TCL compared to those without adverse outcomes (+pEPE: 19.8 vs. 10.1mm, P<0.0001,+pLN: 38.0 vs. 11.7mm, P<0.0001, and BCR: 19.2 vs. 11.2mm, P = 0.001). On multivariate analysis, TCL remained a predictor of+pEPE (odds ratio: 1.04, P = 0.001),+pLN (odds ratio: 1.07, P<0.0001), and BCR (hazard ratio: 1.03, P = 0.02). TCL thresholds for predicting+pEPE and+pLN were 12.5 and 19.7mm, respectively. TCL alone was found to have good predictive ability for+pEPE and+PLN (pEPE:TCL
conclusionWe demonstrate that TCL is an independent predictor of+pEPE, +pLN, and BCR. If validated, this imaging biomarker may facilitate and inform patient counseling and decision-making.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.