SynthesisThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2016
A Systematic Review of Opioid and Benzodiazepine Misuse in Older Adults.
Synthesis in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05037682 (Addressing Opioid Use Disorder in the Elderly Through Primary Care Innovation), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Addressing Opioid Use Disorder in the Elderly Through Primary Care Innovation: Pain and Opioid Management in Older Adults
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Executive summary of the guideline for prescribing opioid analgesics for chronic non-cancer pain (third edition) by the Japan Society of Pain Clinicians.Journal of anesthesia · 2025Guideline
- Cognitive behavioural therapy and third-wave approaches for anxiety and related disorders in older people.The Cochrane database of systematic reviews · 2024Pooled it
- Reducing prescribing of benzodiazepines in older adults: a comparison of four physician-focused interventions by a medical regulatory authority.BMC family practice · 2021Trial
- Positive Airway Pressure Therapy Initiation and Continued Benzodiazepine Use Among Chronic Drug Users.Journal of sleep research · 2026Article
- Supporting family caregivers: Variations in caregiving among families managing chronic health conditions.The American psychologist · 2025Article
- A real-world pharmacovigilance study of lorazepam based on the FDA adverse event reporting system database.Scientific reports · 2025Article
- Article
- The association of prescriber prominence in a shared-patient physician network with their patients receipt of and transitions between risky drug combinations.Applied network science · 2025Article
- Prevalence of Opioid Use in Nursing Homes Over the Last Decade: A Systematic Literature Review.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2024Article
- Accidental substance-related acute toxicity deaths in older adults in 2016 and 2017: a national chart review study.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2024Article
- Article
- Agitated Depression Associated With Flurazepam Discontinuation.Case reports in psychiatry · 2024Article
- Prevalence and Treatment of Substance Misuse in Older Adults: Beyond Early Adulthood.Substance abuse and rehabilitation · 2024Review
- Social Vulnerability and the Prevalence of Opioid Use Disorder Among Older Medicare Beneficiaries in U.S. Counties.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Multiple psychological senses of community and community influences on personal recovery processes from substance use problems in later life: a collaborative and deductive reflexive thematic analysis.International journal of qualitative studies on health and well-being · 2023Article
- Longitudinal latent polysubstance use patterns among a cohort of people who use opioids in Vancouver, Canada.Drug and alcohol review · 2023Article
- Screening the "Invisible Population" of Older Adult Patients for Prescription Pain Reliever Non-Medical Use and Use Disorders.Substance use & misuse · 2023Article
- Opioids Prescribing Among Patients with Zoster-Related Pain in Real-Life: A Retrospective, Cohort Study Based on the Clinical Database.Journal of pain research · 2023Article
- An observational study of the factors associated with frequency of outpatient benzodiazepine prescribing to patients receiving chronic opioid analgesic therapy in primary care at a major academic center.BMC primary care · 2022Observational
- Recent trends in prescription drug misuse in the United States by age, race/ethnicity, and sex.The American journal on addictions · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe authors assessed the prevalence of opioid and benzodiazepine prescription drug misuse in older adults, the risk factors associated with misuse, and age-appropriate interventions.
methodsFollowing PRISMA guidelines, a literature search of PubMed, PsycINFO, and EMBASE for peer-reviewed journal articles in English through April 2014 with updates through November 2015 was conducted for reports on misuse of prescription benzodiazepines and opioids in older adults. Relevant publications were reviewed that included participants age ≥65 years. Reference lists were manually searched for key identified articles and geriatric journals through April 2016. Information on the study design, sample, intervention, comparators, outcome, time frame, and risk of bias were abstracted for each article.
resultsOf 4,932 reviewed reports, 15 were included in this systematic review. Thirteen studies assessed the prevalence of prescription drug misuse and included studies related to opioid shopping behavior, assessment of morbidity and mortality associated with opioid and/or benzodiazepine use, frequency and characteristics of opioid prescribing, frequency of substance use disorders and nonprescription use of pain relievers, and health conditions and experiences of long-term benzodiazepine users. One study identified risk factors for misuse, and one study described the effects of provider education and an electronic support tool as an intervention.
conclusionThere is a dearth of high quality research on prescription drug misuse in older adults. Existing studies are heterogeneous, making it difficult to draw broad conclusions. The need for further research specific to prescription drug misuse among older adults is discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.