ArticlePsychoneuroendocrinology2016
CSF and plasma testosterone in attempted suicide.
Article in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025Review
- High testosterone levels associated with elevated suicidal risk in male adolescents with depression.BMC psychiatry · 2025Article
- A Study of Spontaneous Self-Injurious Behavior and Neuroimaging in Rhesus Macaques.Research (Washington, D.C.) · 2025Article
- Potential association between suicide risk, aggression, impulsivity, and the somatosensory system.Social cognitive and affective neuroscience · 2024Article
- Psychobiological risk factors for suicidal thoughts and behaviors in adolescence: a consideration of the role of puberty.Molecular psychiatry · 2022Review
- New frontiers in suicide vulnerability: immune system and sex hormones.Brain, behavior, & immunity - health · 2021Article
- The Relationship Between Suicide Attempt and Gonadotropins, Gonadal Hormones, and Cortisol in Females.Alpha psychiatry · 2021Article
- An Exploratory Cohort Study of the Association between the Level of Testosterone and Suicidal Ideation in Hospitalized Adolescent Females with Depression in China.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Review
- Normal Testosterone but Higher Luteinizing Hormone Plasma Levels in Men With Hypersexual Disorder.Sexual medicine · 2020Article
- Lipids and Suicide Risk.Current topics in behavioral neurosciences · 2020Article
- GABAFrontiers in neuroscience · 2020Article
- Chronic Testosterone Increases Impulsivity and Influences the Transcriptional Activity of the Alpha-2A Adrenergic Receptor Signaling Pathway in Rat Brain.Molecular neurobiology · 2019Article
- Commentary: CSF and Plasma Testosterone in Attempted Suicide.Frontiers in public health · 2017Article
- Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids.PloS one · 2017Article
- Ambient temperature, testosterone, and suicide.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Very few studies have assessed testosterone levels in the cerebrospinal fluid in suicide attempters. Aggressiveness and impulsivity are common behavioural traits in suicide attempters. Dual-hormone serotonergic theory on human impulsive aggression implies high testosterone/cortisol ratio acting on the amygdala and low serotonin in the prefrontal cortex. Our aim was to examine the CSF and plasma testosterone levels in suicide attempters and in healthy volunteers. We also assessed the relationship between the testosterone/cortisol ratio, aggressiveness and impulsivity in suicide attempters. 28 medication-free suicide attempters and 19 healthy volunteers participated in the study. CSF and plasma testosterone sulfate and cortisol levels were assessed with specific radio-immunoassays. The Karolinska Scales of Personality was used to assess impulsivity and aggressiveness. All patients were followed up for cause of death. The mean follow-up period was 21 years. Male suicide attempters had higher CSF and plasma testosterone levels than age- matched male healthy volunteers. There were no significant differences in CSF testosterone levels in female suicide attempters and healthy female volunteers. Testosterone levels did not differ significantly in suicide victims compared to survivors. In male suicide attempters, the CSF testosterone/cortisol ratio showed a significant positive correlation with both impulsivity and aggressiveness. Higher CSF testosterone levels may be associated with attempted suicide in young men through association with both aggressiveness and impulsivity, a key endophenotype in young male suicide attempters.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.