ArticleEBioMedicine2016
Racial and Socioeconomic Variation in Genetic Markers of Telomere Length: A Cross-Sectional Study of U.S. Older Adults.
Article in EBioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The relationship between physical activity and telomere length in women: A systematic review.Mechanisms of ageing and development · 2025Pooled it
- Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies.Nature communications · 2019Pooled it
- Telomere length and health outcomes: A two-sample genetic instrumental variables analysis.Experimental gerontology · 2016Pooled it
- Investigation of the Characteristics of Telomere Length in Koreans and Its Association With Chronic Metabolic Disorders: A Comprehensive Study.Journal of cellular and molecular medicine · 2025Article
- Resilience Phenotypes and Psychological Functioning among Individuals with Opioid Use Disorder.Substance use & misuse · 2024Article
- Intergenerational effects of maternal lifetime stressor exposure on offspring telomere length in Black and White women.Psychological medicine · 2023Article
- A pilot study examining the relationship between chronic heroin use and telomere length among individuals of African ancestry.Pharmacology, biochemistry, and behavior · 2023Article
- Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression.Scientific reports · 2023Article
- Neighborhood deprivation, racial segregation and associations with cancer risk and outcomes across the cancer-control continuum.Molecular psychiatry · 2023Review
- A Time-Varying Effect Model (TVEM) of the Complex Association of Tobacco Use and Smoke Exposure on Mean Telomere Length: Differences between Racial and Ethnic Groups Assessed in the National Health and Nutrition Examination Survey.International journal of environmental research and public health · 2022Article
- How social/environmental determinants and inflammation affect salivary telomere length among middle-older adults in the health and retirement study.Scientific reports · 2022Article
- A standalone approach to utilize telomere length measurement as a surveillance tool in oral leukoplakia.Molecular oncology · 2022Article
- Prediction of telomere length and telomere attrition using a genetic risk score: The multi-ethnic study of atherosclerosis (MESA).Frontiers in aging · 2022Article
- Identifying genetic risk variants associated with brain volumetric phenotypes via K-sample Ball Divergence method.Genetic epidemiology · 2021Article
- Genetics and geography of leukocyte telomere length in sub-Saharan Africans.Human molecular genetics · 2020Article
- Biological Aging Marker p16Cancers · 2020Article
- Racial discrimination and telomere shortening among African Americans: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2020Article
- Association between common telomere length genetic variants and telomere length in an African population and impacts of HIV and TB.Journal of human genetics · 2019Article
- Influence of rs1746048 SNPs on clinical manifestations and incidence of acute myocardial infarction in Guangxi Han population.International journal of clinical and experimental pathology · 2019Article
- Genetic Determinants of Telomere Length in African American Youth.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundShorter telomere length (TL) has been associated with stress and adverse socioeconomic conditions, yet U.S. blacks have longer TL than whites. The role of genetic versus environmental factors in explaining TL by race and socioeconomic position (SEP) remains unclear.
methodsWe used data from the U.S. Health and Retirement Study (N=11,934) to test the hypothesis that there are differences in TL-associated SNPs by race and SEP. We constructed a TL polygenic risk score (PRS) and examined its association with race/ethnicity, educational attainment, assets, gender, and age.
resultsU.S. blacks were more likely to have a lower PRS for TL, as were older individuals and men. Racial differences in TL were statistically accounted for when controlling for population structure using genetic principal components. The GWAS-derived SNPs for TL, however, may not have consistent associations with TL across different racial/ethnic groups.
conclusionsThis study showed that associations of race/ethnicity with TL differed when accounting for population stratification. The role of race/ethnicity for TL remains uncertain, however, as the genetic determinants of TL may differ by race/ethnicity. Future GWAS samples should include racially diverse participants to allow for better characterization of the determinants of TL in human populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.