Evidence map›Paper›PMID 27566832›Full record

ArticleJournal of leukocyte biology2017

Leukocyte-borne α(1,3)-fucose is a negative regulator of β2-integrin-dependent recruitment in lung inflammation.

Alexander Buffone, Mehrab Nasirikenari, Charles T Manhardt, Amit Lugade, Paul N Bogner, Robert Sackstein, Yasmin Thanavala, Sriram Neelamegham, Joseph T Y Lau

Abstract read
In one paragraph

Article in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Proteoglycans as Mediators of Cancer Tissue Mechanics.Frontiers in cell and developmental biology · 2020
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alexander BuffoneDepartment of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Mehrab NasirikenariDepartment of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Charles T ManhardtDepartment of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Amit LugadeDepartment of Immunology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Paul N BognerDepartment of Pathology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Robert SacksteinDepartment of Dermatology Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Yasmin ThanavalaDepartment of Immunology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Sriram NeelameghamDepartment of Chemical and Biological Engineering, State University of New York at Buffalo, Buffalo, New York, USA.
Joseph T Y LauDepartment of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, USA; joseph.lau@roswellpark.org.
Roswell Park Comprehensive Cancer Center · USUniversity at Buffalo, State University of New York · USHarvard University · US

Funding

REGULATION OF LACTOSAMINYL GLYCAN BIOSYNTHESIS IN HEMATOPOIETIC CELLSP01HL107146 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LAU, JOSEPH TY · 2011 to 2017
$17.7M
Systems Biology of GlycosylationR01HL103411 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI NEELAMEGHAM, SRIRAM · 2011 to 2025
$7.1M
SELECTIN MEDIATED CELL ADHESION UNDER HYDRODYNAMIC SHEARR01HL063014 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI NEELAMEGHAM, SRIRAM · 2001 to 2014
$3.0M
NHLBI NIH HHS P01 HL107146NHLBI NIH HHS R01 HL063014NHLBI NIH HHS R01 HL103411
6 · The paper itself

Abstract

Leukocyte recruitment in inflammation is a multistep, sequential cascade where the initial step is the selectin-dependent tethering, followed by the formation of firmer integrin-mediated adhesive forces leading to extravasation. The α(1,3)-fucose-containing sialyl-Lewis X (sLe

Indexed as

AnimalsCD18 AntigensCell AdhesionCell CommunicationDisease Models, AnimalFucoseFucosyltransferasesIntercellular Adhesion Molecule-1LeukocytesLigandsLungMiceMice, Inbred C57BLModels, BiologicalN-Acetylneuraminic AcidNeutrophilsCD18 AntigensFucoseFucosyltransferasesIntercellular Adhesion Molecule-1LigandsN-Acetylneuraminic AcidReceptors, Interleukin-8BSelectinsCXCR2fucosyltransferaseICAM-1neutrophilNTHI

Identifiers

PMID27566832
PMCPMC6608008
OpenAlexW2511348540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.