Evidence map›Paper›PMID 27566671›Full record

Trial reportBMC nephrology2016

Vitamins (A, C and E) and oxidative status of hemodialysis patients treated with HFR and HFR-Supra.

Simonetta Palleschi, Paolo M Ghezzi, Giuseppe Palladino, Barbara Rossi, Marino Ganadu, Domenica Casu, Maria Cossu, Giovanni Mattana, Antonio Maria Pinna, Bruno Contu and 9 more

Registry-linked trialOpen access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01492491 (Collaborative Study on Outcome of Antioxidant Vitamines, Microinflammation Parameters and Middle-high Toxins in ESRD Patients Treated With Online HDF, HFR and SUPRA-HFR), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01492491 phase3completednot on this map

Collaborative Study on Outcome of Antioxidant Vitamines, Microinflammation Parameters and Middle-high Toxins in ESRD Patients Treated With Online HDF, HFR and SUPRA-HFR

TypeinterventionalSponsorAzienda Sanitaria Locale di CagliariRan2011 to 2013Enrolled50ConditionsInflammationArmsSUPRA-HFR
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 1 country.

Simonetta PalleschiDepartment of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Paolo M GhezziMedical Scientific Consultant of Bellco s.r.l. Company, Mirandola, Italy.
Giuseppe PalladinoBellco s.r.l Company, Mirandola, Italy.
Barbara RossiDepartment of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Marino GanaduOspedale A.Segni, Ozieri, Italy.
Domenica CasuOspedale Civile, Alghero, Italy.
Maria CossuOspedale SS. Annunziata, Sassari, Italy.
Giovanni MattanaOspedale S. Francesco, Nuoro, Italy.
Antonio Maria PinnaOspedale S. Martino, Oristano, Italy.
Bruno ContuOspedale N.S. della Mercede, Lanusei, Italy.
Tonina GhisuASL 3, Macomer, Italy.
Alessandro MonniOspedale SS. Trinità, Cagliari, Italy.
Luana GazzanelliOspedale P. Merlo, La Maddalena, Italy.
Maria Cristina MereuOspedale N.S. di Bonaria, S. Gavino Monreale, Italy.
Franco LogiasOspedale S. Francesco, Nuoro, Italy.
Mario PassagheOspedale P. Dettori, Tempio Pausania, Italy.
Alessandro AmoreOspedale Infantile Regina Margherita, Torino, Italy.
Piergiorgio BolascoTerritorial Unit of Nephrology and Dialysis , ASL 8 of Cagliari, Cagliari, Italy. pg.bolasco@tin.it.ORCID 0000-0001-9788-2342
Sardinian Study Group
Istituto Superiore di Sanità · ITFondazione Centro Marino Internazionale · ITOspedale Civile di Voghera · ITSantissima Trinità · ITUniversity of Cagliari · ITLa Maddalena · ITOspedale Regina Margherita · ITOspedale SS. Annunziata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemodiafiltration with on-line endogenous reinfusion (HFR) is an extracorporeal dialytic method that combines diffusion, convection and adsorption. HFR-Supra (HFR-S) is a second-generation system with increased convective permeability and adsorption capability. Previous studies suggested that HFR reduces oxidative stress compared to standard haemodialysis. The principal aim of the present study was to compare antioxidant vitamins behavior and oxidative status of hemodialysis patients treated with HFR and HFR-S.

methodsThe study was designed as a multicenter, randomized, crossover trial. Forty-one patients were recruited from 19 dialysis centers and after a 4-month washout stabilization period in on-line hemodiafiltration (ol-HDF), each patient was randomized to a sequence of treatments (HFR-S followed by HFR or viceversa) with each treatment applied over 6 months. Plasma levels of Advanced Oxidation Protein Products, Total Antioxidant Status, vitamins C, A and E and their ligands (Retinol Binding Protein and total lipids) were measured at baseline and at the end of each treatment period.

resultsResults show that the higher convective permeability of HFR-S with respect to HFR did not produce additional beneficial effects on the patients' oxidative status, a slight decrease of both Vitamin A and Retinol Binding Protein being the only difference registered in the long-term. However, as compared to ol-HDF, both the re-infusive techniques allowed to reduce the intradialytic loss of Vitamin C and, in the long-term, improve the patients' oxidative status and increase Retinol Binding Protein plasma values. No significant differences were found between the Vitamin C concentration of pre- and post cartridge UF neither in HFR-S nor in HFR showing that the sorbent resin does not adsorb Vitamin C.

conclusionHFR-S and HFR are almost equivalent in term of impact on antioxidant vitamins and oxidative status of hemodialysis patients. Nonetheless, as compared to ol-HDF, both treatments produced a sensible sparing of Vitamin C and may represent a new approach for reducing oxidative stress and related complications in dialysis patients. Long-term effects of re-infusive treatments on patients' cardiovascular morbidity and mortality need to be evaluated.

trial registrationClinicalTrials.gov Identifier NCT01492491 , retrospectively registered in 10 December 2011.

Indexed as

AdultAdvanced Oxidation Protein ProductsAgedAged, 80 and overAntioxidantsAscorbic AcidCross-Over StudiesFemaleHemodiafiltrationHumansKidney Failure, ChronicLipidsMaleMiddle AgedOxidative StressProspective StudiesAdvanced Oxidation Protein ProductsAntioxidantsAscorbic AcidLipidsRetinol-Binding Proteins, PlasmaVitamin AVitamin EAdsorptionAntioxidantsHemodiafiltrationHFRHigh permeabilityOxidative stressVitamins

Identifiers

PMID27566671
PMCPMC5002141
OpenAlexW2509918799

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.