ArticleMicrobiology (Reading, England)2016
Identification and characterization of a haem biosynthesis locus in Veillonella.
Article in Microbiology (Reading, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- The association between self-reported vaping and the human oral microbiome: a systematic review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Pooled it
- Impact of Electronic Cigarette Use on the Oral Microbiota: A Systematic Review.Journal of clinical periodontology · 2026Pooled it
- Association between red biofluorescence and microbial dysbiosis in cariogenic biofilms: an in vitro study.Scientific reports · 2026Article
- Establishment of a HicA toxin-based counterselection system for markerless genetic engineering in Veillonella atypica OK5.BMC microbiology · 2026Article
- Fluorescence-Based In Vitro Detection of Wound-Associated Bacteria with a Handheld Imaging System.Diagnostics (Basel, Switzerland) · 2025Article
- Causal association between oral microbiota and oral cancer: a mendelian randomization study.Scientific reports · 2025Article
- Exploring heme and iron acquisition strategies of Porphyromonas gingivalis-current facts and hypotheses.FEMS microbiology reviews · 2025Review
- Linking peri-implantitis to microbiome changes in affected implants, healthy implants, and saliva: a cross-sectional pilot study.Frontiers in cellular and infection microbiology · 2025Article
- Development of a small shuttle plasmid for use in oral Veillonella and initial appraisal of potential for fluorescence-based applications.Letters in applied microbiology · 2024Article
- Multi-omic integration of microbiome data for identifying disease-associated modules.Nature communications · 2024Article
- Illuminating the oral microbiome and its host interactions: tools and approaches for molecular microbiology studies.FEMS microbiology reviews · 2023Review
- Comparison of antibacterial and antibiofilm activity of bioactive glass compounds S53P4 and 45S5.BMC microbiology · 2022Article
- Veillonellaceae family members uniquely alter the cervical metabolic microenvironment in a human three-dimensional epithelial model.NPJ biofilms and microbiomes · 2021Article
- Veillonellae: Beyond Bridging Species in Oral Biofilm Ecology.Frontiers in oral health · 2021Review
- Periodontal Disease: The Good, The Bad, and The Unknown.Frontiers in cellular and infection microbiology · 2021Review
- Sulfated vizantin causes detachment of biofilms composed mainly of the genus Streptococcus without affecting bacterial growth and viability.BMC microbiology · 2020Article
- [Research progress in the relationship between Veillonella and oral diseases].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020Review
- Clinical Detection of Chronic Rhinosinusitis through Next-Generation Sequencing of the Oral Microbiota.Microorganisms · 2020Article
- Article
- Veillonella Catalase Protects the Growth of Fusobacterium nucleatum in Microaerophilic and Streptococcus gordonii-Resident Environments.Applied and environmental microbiology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Haemin/haem is one of the essential nutrients required by periodontopathogens such as Porphyromonas gingivalis to grow in vitro. In the oral cavity, this nutrient is believed to be provided by the crevicular fluid, a serum-like exudate produced during gum inflammation. However, P. gingivalis is also present in the healthy dental biofilm where inflammation is absent. This study was designed to answer the question: what organism(s) in the healthy dental biofilm provides haemin/haem to those periodontal pathogens? We report here that veillonellae, a group of bridging species in dental biofilm development, harbour a complete gene cluster for haem biosynthesis. Haemin production was detected from cell lysate, suggesting that the haem biosynthesis pathway is functional in veillonellae. Using the only transformable strain Veillonella atypica OK5, we inactivated specific key genes in the haem biosynthesis pathway. Inactivation of hemE, encoding the enzyme uroporphyrinogen decarboxylase, not only abolished haemin production but also significantly decreased OK5-supported growth of P. gingivalis. A luciferase gene reporter to the hemEHG operon demonstrated up-regulation of operon expression by P. gingivalis. Analysis of all sequenced genomes of oral bacteria in the HOMD database identified three genera (Veillonella, Propionibacterium and Aggregatibacter) that have a complete haem biosynthesis gene cluster, suggesting that they all could be potential haemin/haem providers in the dental biofilm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.