ArticleOncotarget2016
(-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Antimicrobial: Antibiofilm, Anti-Quorum Sensing and Cytotoxic Activities ofAntibiotics (Basel, Switzerland) · 2025Article
- Article
- Article
- (-)-Guaiol triggers immunogenic cell death and inhibits tumor growth in non-small cell lung cancer.Molecular and cellular biochemistry · 2023Article
- Insight into the Biological Roles and Mechanisms of Phytochemicals in Different Types of Cancer: Targeting Cancer Therapeutics.Nutrients · 2023Review
- Terpenes and Cannabinoids in Supercritical COPharmaceuticals (Basel, Switzerland) · 2022Article
- Integrating Network Pharmacology, Molecular Docking, and Experimental Validation to Investigate the Mechanism of (-)-Guaiol Against Lung Adenocarcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Exploring the Roles of Dietary Herbal Essential Oils in Aquaculture: A Review.Animals : an open access journal from MDPI · 2022Review
- The Medicinal Natural Products ofMolecules (Basel, Switzerland) · 2022Review
- Article
- Biological Properties ofEvidence-based complementary and alternative medicine : eCAM · 2022Review
- Antinociceptive effect and mechanism of supercritical carbon dioxide extract of Aloysia gratissima leaves in mice.Biomedical journal · 2021Article
- Epigenomic Analysis of RAD51 ChIP-seq Data RevealsCancers · 2021Article
- Terpenes/Terpenoids inMedical cannabis and cannabinoids · 2020Article
- Review
- Article
- Article
- (-)-Guaiol regulates autophagic cell death depending on mTOR signaling in NSCLC.Cancer biology & therapy · 2018Article
- RAP80 is an independent prognosis biomarker for the outcome of patients with esophageal squamous cell carcinoma.Cell death & disease · 2018Article
- Antibacterial and Antioxidant Constituents of Extracts of Endophytic Fungi Isolated from Ocimum basilicum var. thyrsiflora Leaves.Current microbiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(-)-Guaiol, generally known as an antibacterial compound, has been found in many medicinal plants. Its roles in tumor suppression are still under investigation. In the study, we mainly focused on exploring its applications in dealing with non-small cell lung cancer (NSCLC) and the underlying mechanisms. Here, we show that (-)-Guaiol significantly inhibits cell growth of NSCLC cells both in vitro and in vivo. Further high throughput analysis reveals that RAD51, a pivotal factor in homologous recombination repair, is a potential target for it. The following mechanism studies show that (-)-Guaiol is involved in cell autophagy to regulate the expression of RAD51, leading to double-strand breaks triggered cell apoptosis. Moreover, targeting RAD51, which is highly overexpressed in the lung adenocarcinoma tissues, can significantly increase the chemosensitivity of NSCLC cells to (-)-Guaiol both in vitro and in vivo. All in all, our studies provide an attractive insight in applying (-)-Guaiol into NSCLC treatments and further suggest that knockdown of oncogenic RAD51 will greatly enhance the chemosensitivity of patients with NSCLC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.