ArticleOncotarget2016
Infarct volume after glioblastoma surgery as an independent prognostic factor.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Pooled it
- Impact of ischemic preconditioning on surgical treatment of brain tumors: a single-center, randomized, double-blind, controlled trial.BMC medicine · 2017Trial
- Postoperative ischemia and neurological deficits after glioma resection: A systematic review and meta-analysis.Neuro-oncology practice · 2026Review
- Surgical decision making in the era of supramarginal glioma resections: a current perspective and narrative review.CNS oncology · 2025Review
- Measures of physical functioning in adults with brain tumor associated with functional outcomes: A scoping review.Neuro-oncology practice · 2025Review
- Survival implications of postoperative restricted diffusion in high-grade glioma and limitations of intraoperative MRI detection.Journal of neuro-oncology · 2024Article
- Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy.PLoS computational biology · 2024Article
- Mini-strokes after awake surgery for glioma resection: are there anesthesia related factors?Acta neurochirurgica · 2024Article
- Optimal timing of radiotherapy following brain metastases surgery.Neuro-oncology practice · 2022Article
- Early Therapeutic Interventions for Newly Diagnosed Glioblastoma: Rationale and Review of the Literature.Current oncology reports · 2022Review
- Subcortical motor ischemia can be detected by intraoperative MRI within 1 h - A feasibility study.Brain & spine · 2022Article
- Brain infarctions after glioma surgery: prevalence, radiological characteristics and risk factors.Acta neurochirurgica · 2021Article
- Conventional and advanced imaging throughout the cycle of care of gliomas.Neurosurgical review · 2021Review
- Mapping and Preserving the Visuospatial Network by repetitive nTMS and DTI Tractography in Patients With Right Parietal Lobe Tumors.Frontiers in oncology · 2021Article
- Metabolic Parameters Influence Brain Infarction and Outcome after Resection of Brain Metastases.Cancers · 2020Article
- Retrospective Analysis of Radiological Recurrence Patterns in Glioblastoma, Their Prognostic Value And Association to Postoperative Infarct Volume.Scientific reports · 2018Article
- Safe Brain Tumor Resection Does not Depend on Surgery Alone - Role of Hemodynamics.Scientific reports · 2017Article
- The impact of postoperative ischemic changes on survival outcomes in IDH-wildtype glioblastoma.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative ischemia is associated with reduced functional independence measured by karnofsky performance score (KPS), which correlates well with overall survival. Other studies suggest that postoperative hypoxia might initiate infiltrative tumor growth. Therefore, aim of this study was to analyze the impact of infarct volume on overall survival and progression free survival (PFS) of glioblastoma patients.251 patients with surgery for a newly diagnosed glioblastoma (WHO IV) were retrospectively assessed. Pre- and postoperative KPS, date of death/last follow-up and histopathological markers were recorded. Pre- and postoperative tumor volume and the volume of postoperative infarction were manually segmented.A significant correlation of infarct volume with postoperative KPS decrease (P = 0.001) was observed. Infarct volume showed a significant impact on overall survival (P = 0.014), but not on PFS (P = 0.112) in univariate analysis. This effect increased in the subgroup of patients with near-total tumor resection (> 90%) (overall survival: P = 0.006, PFS: P = 0.066). Infarct volume remained as an independent prognostic factor for overall survival in multivariate analysis (HR 1.013 [1.000-1.026], P = 0.042) including other prognostic factors (age, extent of resection, postoperative KPS).Postoperative infarct volume significantly correlates as an independent factor with overall survival after glioblastoma surgery. Besides the influence of perioperative infarction on postoperative KPS, postoperative hypoxia might also have an effect on tumor biology initiating infiltrative growth and therefore impaired survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.