Evidence map›Paper›PMID 27566471›Full record

ReviewThe Journal of membrane biology2017

Functional Membrane Microdomains Organize Signaling Networks in Bacteria.

Rabea M Wagner, Lara Kricks, Daniel Lopez

Abstract readReview
PubMed Publisher
In one paragraph

Review in The Journal of membrane biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Toxic Effects of Butanol in the Plane of the Cell Membrane.Langmuir : the ACS journal of surfaces and colloids · 2025
    Article
  2. Article
  3. Review
  4. Infection and immunity · 2023
    Article
  5. Review
  6. Flotillins: At the Intersection of ProteinInternational journal of molecular sciences · 2020
    Review
  7. Impact of Fatty-Acid Labeling ofFrontiers in microbiology · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Rabea M WagnerResearch Centre for Infectious Diseases (ZINF), University of Würzburg, 97080, Würzburg, Germany.
Lara KricksResearch Centre for Infectious Diseases (ZINF), University of Würzburg, 97080, Würzburg, Germany.
Daniel LopezResearch Centre for Infectious Diseases (ZINF), University of Würzburg, 97080, Würzburg, Germany. dlopez@cnb.csic.es.
University of Würzburg · DECentro Nacional de Biotecnología · ES

Funding

European Research Council 335568Secretaría de Estado de Investigación, Desarrollo e Innovación BFU2014-55601-P
6 · The paper itself

Abstract

Membrane organization is usually associated with the correct function of a number of cellular processes in eukaryotic cells as diverse as signal transduction, protein sorting, membrane trafficking, or pathogen invasion. It has been recently discovered that bacterial membranes are able to compartmentalize their signal transduction pathways in functional membrane microdomains (FMMs). In this review article, we discuss the biological significance of the existence of FMMs in bacteria and comment on possible beneficial roles that FMMs play on the harbored signal transduction cascades. Moreover, four different membrane-associated signal transduction cascades whose functions are linked to the integrity of FMMs are introduced, and the specific role that FMMs play in stabilizing and promoting interactions of their signaling components is discussed. Altogether, FMMs seem to play a relevant role in promoting more efficient activation of signal transduction cascades in bacterial cells and show that bacteria are more sophisticated organisms than previously appreciated.

Indexed as

Gene Expression Regulation, BacterialSignal TransductionATP-Dependent ProteasesBacillus subtilisBacterial ProteinsBiofilmsCell CompartmentationCell WallEscherichia coliEscherichia coli ProteinsMembrane LipidsMembrane MicrodomainsMembrane ProteinsNucleotidyltransferasesProtein MultimerizationRepressor ProteinsATP-Dependent ProteasesBacterial ProteinsEscherichia coli ProteinsflotillinsFtsH protein, E coliMembrane LipidsMembrane ProteinsNucleotidyltransferasesPhoP protein, BacteriaPhoR protein, BacteriaRepressor ProteinsresD protein, E coliBacterial membranesMembrane microdomainsSignal transduction

Identifiers

PMID27566471
OpenAlexW2511270157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.