ArticleLiver international : official journal of the International Association for the Study of the Liver2017
Association between diabetes mellitus and cirrhosis mortality: the Singapore Chinese Health Study.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Pooled it
- Syndemic analysis of stroke in Indonesia.The Lancet regional health. Western Pacific · 2026Article
- Association of a history of type 2 diabetes with short-term mortality in patients with decompensated cirrhosis.Frontiers in endocrinology · 2026Article
- Diabetes as a Risk Factor for Sarcopenia in Patients with MASH-Related Cirrhosis.Journal of clinical medicine · 2025Article
- Association Between a Diabetes Risk Reduction Diet and Mortality From Chronic Liver Disease.Cureus · 2025Article
- Risks of liver cirrhosis, hepatocellular carcinoma, hepatic-related complications, and mortality in patients with type 2 diabetes in Taiwan.World journal of diabetes · 2025Article
- Correspondence to editorial on "Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy: A multicenter study for chronic hepatitis C".Clinical and molecular hepatology · 2025Article
- Comparison Between the Impact of Diabetes Mellitus on Liver Diseases and Vice Versa Among Saudi and Egyptian Patients.Healthcare (Basel, Switzerland) · 2025Article
- The mediating role of wellbeing in the relationship between health behaviors and quality of life in people with hepatogenous diabetes.Frontiers in public health · 2025Article
- Diabetes risk reduction diet and risk of liver cancer and chronic liver disease mortality: A prospective cohort study.Journal of internal medicine · 2024Observational
- Effect of diabetes on mortality and liver transplantation in alcoholic liver cirrhotic patients with acute decompensation.Hepatology international · 2024Article
- Trends in Mortality of Cirrhosis in China: An Analysis of the China Death Surveillance Database from 2008 to 2020.Journal of clinical and translational hepatology · 2024Article
- Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review.Journal of obesity & metabolic syndrome · 2023Review
- [Expert consensus on the management of diabetes mellitus in patients with liver cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- Type 2 Diabetes, PNPLA3 rs738409 Polymorphism, and the Risk of Liver Cirrhosis: Analysis of Taiwan Biobank.Frontiers in genetics · 2022Article
- Type 2 Diabetes: A Risk Factor for Hospital Readmissions and Mortality in Australian Patients With Cirrhosis.Hepatology communications · 2020Article
- Late Evening Snack with Branched-Chain Amino Acids Supplementation Improves Survival in Patients with Cirrhosis.Journal of clinical medicine · 2020Article
- Clinical spectrum of non-alcoholic fatty liver disease in patients with diabetes mellitus.PloS one · 2020Article
- Development and Validation of CAGIB Score for Evaluating the Prognosis of Cirrhosis with Acute Gastrointestinal Bleeding: A Retrospective Multicenter Study.Advances in therapy · 2019Article
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5 authors at 4 institutions in 3 countries.
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Abstract
BACKGROUND &
aimDiabetes mellitus has been linked to cirrhosis-related mortality in Western populations, but less is known about this relationship in Asian populations. We studied the impact of diabetes on the risk of cirrhosis mortality in a population-based cohort among Chinese in Singapore.
methodsWe used data collected and analysed from the Singapore Chinese Health Study, a prospective community-based cohort of 63 275 subjects aged 45-74 years during enrolment between 1993 and 1998. Information on diet, lifestyle and medical history was collected via structured questionnaire. Mortality cases from cirrhosis in the cohort were identified via linkage with nationwide death registry up to 31 December 2014. Cox proportional regression models were used to estimate the associations with adjustment for risk factors of cirrhosis.
resultsAfter a mean follow-up of 16.9 years, there were 133 deaths from cirrhosis. Diabetes was associated with an increased risk of cirrhosis mortality (hazard ratio [HR]: 2.80; 95% confidence interval [CI]: 2.04-3.83), and for both viral (HR: 2.20; 95% CI: 1.18-4.11) and non-viral hepatitis-related cirrhosis mortality (HR: 3.06; 95% CI: 2.13-4.41). The association between diabetes and non-viral hepatitis-related cirrhosis mortality was stronger among participants of body mass index (BMI) less than 23 kg/m
conclusionDiabetes is a risk factor for cirrhosis mortality, especially for non-viral hepatitis-related cirrhosis in population with BMI considered low or normal in Asia.
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