Evidence map›Paper›PMID 27566419›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2017

Postdiagnosis Weight Change and Survival Following a Diagnosis of Early-Stage Breast Cancer.

Elizabeth M Cespedes Feliciano, Candyce H Kroenke, Patrick T Bradshaw, Wendy Y Chen, Carla M Prado, Erin K Weltzien, Adrienne L Castillo, Bette J Caan

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elizabeth M Cespedes FelicianoDivision of Research, Kaiser Permanente Northern California, Oakland, California. elizabeth.m.cespedes@kp.org.
Candyce H KroenkeDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Patrick T BradshawDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California.
Wendy Y ChenChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Carla M PradoDepartment of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada.
Erin K WeltzienDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Adrienne L CastilloDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Bette J CaanDivision of Research, Kaiser Permanente Northern California, Oakland, California.

Funding

(PQA2) Exploring the role of sarcopenia in obesity and breast cancer survivalR01CA184953 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI CAAN, BETTE J · 2014 to 2017
$2.5M
NCI NIH HHS R01 CA184953
6 · The paper itself

Abstract

backgroundAchieving a healthy weight is recommended for all breast cancer survivors. Previous research on postdiagnosis weight change and mortality had conflicting results.

methodsWe examined whether change in body weight in the 18 months following diagnosis is associated with overall and breast cancer-specific mortality in a cohort of n = 12,590 stage I-III breast cancer patients at Kaiser Permanente using multivariable-adjusted Cox regression models. Follow-up was from the date of the postdiagnosis weight at 18 months until death or June 2015 [median follow-up (range): 3 (0-9) years]. We divided follow-up into earlier (18-54 months) and later (>54 months) postdiagnosis periods.

resultsMean (SD) age-at-diagnosis was 59 (11) years. A total of 980 women died, 503 from breast cancer. Most women maintained weight within 5% of diagnosis body weight; weight loss and gain were equally common at 19% each. Compared with weight maintenance, large losses (≥10%) were associated with worse survival, with HRs and 95% confidence intervals (CI) for all-cause death of 2.63 (2.12-3.26) earlier and 1.60 (1.14-2.25) later in follow-up. Modest losses (>5%-<10%) were associated with worse survival earlier [1.39 (1.11-1.74)] but not later in follow-up [0.77 (0.54-1.11)]. Weight gain was not related to survival. Results were similar for breast cancer-specific death.

conclusionLarge postdiagnosis weight loss is associated with worse survival in both earlier and later postdiagnosis periods, independent of treatment and prognostic factors. IMPACT: Weight loss and gain are equally common after breast cancer, and weight loss is a consistent marker of mortality risk. Cancer Epidemiol Biomarkers Prev; 26(1); 44-50. ©2016 AACR SEE ALL THE ARTICLES IN THIS CEBP FOCUS SECTION, "THE OBESITY PARADOX IN CANCER EVIDENCE AND NEW DIRECTIONS".

Indexed as

Body Mass IndexCause of DeathAgedAge FactorsBody WeightBreast NeoplasmsCaliforniaCohort StudiesDatabases, FactualDisease-Free SurvivalFemaleFollow-Up StudiesHumansMiddle AgedMultivariate AnalysisNeoplasm Invasiveness

Identifiers

PMID27566419
PMCPMC5224999

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.