ArticleBMC infectious diseases2016
Prevalence, risk factors for infection and subtype distribution of the intestinal parasite Blastocystis sp. from a large-scale multi-center study in France.
Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76 citing papers in PubMed, 143 citations in OpenAlex.
- Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the single-cell fecal parasitome in children with celiac disease autoimmunity: a randomized, double-blind placebo-controlled clinical trial.Parasites & vectors · 2023Trial
- First Molecular Detection and Genotypic Characterization of Enterocytozoon bieneusi and Blastocystis in Farmed Chukar Partridges (Alectoris chukar) in Southern China.Acta parasitologica · 2026Article
- First survey on the occurrence, subtype distribution and circulation of the enteric protozoan Blastocystis sp. in French broiler chicken farms.Poultry science · 2026Article
- Occurrence and subtyping of the intestinal protozoanFood and waterborne parasitology · 2026Article
- Epidemiology and clinical characteristics of intestinal parasites among patients of a medical center in central Taiwan: a retrospective study of Blastocystis infection.Tropical medicine and health · 2026Article
- Molecular Prevalence and Genetic Diversity of Blastocystis sp. in Slaughtered Ruminants in Qazvin Province, Iran: A Zoonotic Concern.Veterinary medicine and science · 2026Article
- First molecular identification and genetic diversity of Giardia duodenalis and Blastocystis sp. in patients with multiple sclerosis in Iran.Molecular biology reports · 2025Article
- Co-infection and interaction of enteric pathogens in acute diarrhea among children under five years: a large-scale multicenter observational study from China.Infectious diseases of poverty · 2025Observational
- Shaping the human gut microbiota: The role of canine companionship, lifestyle choices, andOne health (Amsterdam, Netherlands) · 2025Article
- Edible plants as significant sources ofFood and waterborne parasitology · 2025Review
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- Schistosomiasis and soil-transmitted helminthiasis prevalence and associated factors among school children in the Hawela Tula sub-city, Ethiopia: a cross-sectional study.Frontiers in epidemiology · 2025Article
- A cross-sectional survey ofOne health (Amsterdam, Netherlands) · 2024Article
- Current status of intestinal parasitosis and microsporidiosis in industrialized countries: Results from a prospective study in France and Luxembourg.PLoS neglected tropical diseases · 2024Article
- Effective Laboratory Diagnosis of Parasitic Infections of the Gastrointestinal Tract: Where, When, How, and What Should We Look For?Diagnostics (Basel, Switzerland) · 2024Review
- Unveiling Blastocystis epidemiology in Morocco: subtype diversity among clinical patients with and without gastrointestinal manifestations in the Meknes region.Parasitology research · 2024Article
- Blastocystis colonization and associations with population parameters in Thai adults.PLoS neglected tropical diseases · 2024Article
- Subtype Distribution ofMicroorganisms · 2024Article
- Review
- Diversity and composition of gut protist in young rural Zimbabwean children.Frontiers in microbiomes · 2024Article
16 more citing papers are in PubMed but not listed here.
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21 authors at 10 institutions in 1 country.
Funding
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Abstract
backgroundBlastocystis sp. is the most common intestinal parasite of humans. Despite its potential public health impact, epidemiological data regarding the prevalence and molecular subtype distribution of Blastocystis sp. in Europe are rarely reported. Therefore, the first multi-center epidemiological survey performed in Europe was conducted in France to diagnose and subtype Blastocystis sp. and to identify risk factors for infection.
methodsStool samples from 788 patients were collected either in summer or winter in 11 hospitals throughout France together with patient data. All stool samples were tested for the presence of Blastocystis sp. by quantitative PCR targeting the SSU rDNA gene. Positive samples were sequenced to determine the distribution of the subtypes in our cohort. Statistical analyses were performed to identify potential risk factors for infection.
resultsUsing quantitative PCR, the overall prevalence of Blastocystis sp. was shown to reach 18.1 %. The prevalence was significantly higher in summer (23.2 %) than in winter (13.7 %). Travellers or subjects infected with other enteric parasites were significantly more infected by Blastocystis sp. than non-travellers or subjects free of other enteric parasites, respectively. Different age-related epidemiological patterns were also highlighted from our data. The prevalence of Blastocystis sp. was not significantly higher in patients with digestive symptoms or diagnosed with chronic bowel diseases. Among symptomatic patients, Blastocystis sp. infection was significantly associated with abdominal pain. Gender, socioeconomic status, and immune status were not identified as potential risk factors associated with infection. Among a total of 141 subtyped isolates, subtype 3 was predominant (43.3 %), followed by subtype 1 and subtype 4 (20 %), subtype 2 (12.8 %), subtype 6 and subtype 7 (2.1 %). No association between ST and clinical symptoms was statistically evidenced.
conclusionsA high prevalence of Blastocystis sp. infection was found in our French patient population. Seasonal impact on the prevalence of Blastocystis sp. was highlighted and recent travels and age were identified as main risk factors for infection. Most cases were caused by subtypes 1 to 4, with a predominance of subtype 3. Large variations in both prevalence and ST distribution between hospitals were also observed, suggesting distinct reservoirs and transmission sources of the parasite.
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