ArticleHeart (British Cardiac Society)2017
Reduced haemodynamic coupling and exercise are associated with vascular stiffening in pulmonary arterial hypertension.
Article in Heart (British Cardiac Society), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Physiologic relevance of the transpulmonary metabolome in connective tissue disease-associated pulmonary vascular disease.JCI insight · 2025Article
- LOXL2 inhibition ameliorates pulmonary artery remodeling in pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Poor cardiac output reserve in pulmonary arterial hypertension is associated with right ventricular stiffness and impaired interventricular dependence.The European respiratory journal · 2024Article
- A novel complement C3 inhibitor CP40-KK protects against experimental pulmonary arterial hypertension via an inflammasome NLRP3 associated pathway.Journal of translational medicine · 2024Article
- Distensibility, an Early Disease Marker of Pulmonary Vascular Health: Ready for Clinical Application.Journal of the American Heart Association · 2023Article
- Classification and Predictors of Right Ventricular Functional Recovery in Pulmonary Arterial Hypertension.Circulation. Heart failure · 2023Article
- The physiological basis of pulmonary arterial hypertension.The European respiratory journal · 2022Review
- Are you Coupled? Hemodynamic Phenotyping in Pulmonary Hypertension.Function (Oxford, England) · 2022Article
- Multimodality Deep Phenotyping Methods to Assess Mechanisms of Poor Right Ventricular-Pulmonary Artery Coupling.Function (Oxford, England) · 2022Article
- Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling.Biomolecules · 2021Article
- Contrasting haemodynamic effects of exercise and saline infusion in older adults with pulmonary arterial hypertension.ERJ open research · 2021Article
- Pulmonary Vascular and Right Ventricular Burden During Exercise in Interstitial Lung Disease.Chest · 2020Article
- Prognostic value of mean velocity at the pulmonary artery estimated by cardiovascular magnetic resonance as a prognostic predictor in a cohort of patients with new-onset heart failure with reduced ejection fraction.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- EXPRESS: Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI).Pulmonary circulation · 2019Article
- Right Ventricular-Pulmonary Vascular Interactions.Physiology (Bethesda, Md.) · 2017Review
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveInadequate right ventricular (RV) and pulmonary arterial (PA) functional responses to exercise are important yet poorly understood features of pulmonary arterial hypertension (PAH). This study combined invasive catheterisation with echocardiography to assess RV afterload, RV function and ventricular-vascular coupling in subjects with PAH.
methodsTwenty-six subjects with PAH were prospectively recruited to undergo right heart catheterisation and Doppler echocardiography at rest and during incremental exercise, and cardiac MRI at rest. Measurements at rest included basic haemodynamics, RV function and coupling efficiency (η). Measurements during incremental exercise included pulmonary vascular resistance (Z
resultsIn patients with PAH, the proximal PAs were significantly stiffer at maximum exercise (Z
conclusionsIn PAH, exercise causes proximal and distal PA stiffening, which combined with preserved Z
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Registered trials
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