ArticleJournal of neurotrauma2017
Effects of Stand and Step Training with Epidural Stimulation on Motor Function for Standing in Chronic Complete Paraplegics.
Article in Journal of neurotrauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 78 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Spinal Epidural Electrode Array to Facilitate Standing and Stepping After Spinal Cord Injury
Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury
Who cites it
78 citing papers in PubMed.
- Cervical and thoracolumbar transspinal stimulation at 0.3 Hz and 30 Hz facilitates neuronal excitability in healthy humans: a randomized cross-over study.Experimental brain research · 2025Trial
- Activity-based recovery training with spinal cord epidural stimulation improves standing performance in cervical spinal cord injury.Journal of neuroengineering and rehabilitation · 2025Trial
- Electrophysiological Guidance of Epidural Electrode Array Implantation over the Human Lumbosacral Spinal Cord to Enable Motor Function after Chronic Paralysis.Journal of neurotrauma · 2019Trial
- Trial
- Spinal cord lesion characteristics and early standing ability with and without epidural stimulation.Experimental brain research · 2026Article
- Robotic trunk perturbation magnitude affects standing postural responses in individuals with motor complete spinal cord injury receiving epidural stimulation.Scientific reports · 2026Article
- Research progress on the effects of epidural electrical stimulation on lower extremity function in patients with spinal cord injury.Frontiers in medicine · 2026Review
- Therapeutic Effects of Noninvasive Technology Modalities on Lower-Limb Motor Function in Spinal Cord Injury: A Systematic Review.Archives of rehabilitation research and clinical translation · 2025Review
- Functional motor mapping of domestic pig lumbar spinal cord using penetrating microelectrodes.Journal of neuroengineering and rehabilitation · 2025Article
- Transcutaneous spinal cord stimulation at alternating intensities preferentially prevents the development of spasticity after contusion SCI in rat.The Journal of physiology · 2025Article
- Responsiveness to transcutaneous spinal stimulation for upper extremity recovery following spinal cord injury: A case series exploration of midsagittal tissue bridges.The journal of spinal cord medicine · 2025Article
- Mechanism-Based Neuromodulation in Augmenting Respiratory Motor Function in Individuals with Spinal Cord Injury.Journal of clinical medicine · 2025Review
- Activity of spinal RORβ neurons is related to functional improvements following combination treatment after complete SCI.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Potential of Spinal Cord Stimulation in Treating Spinal Cord Injury.Current pain and headache reports · 2025Review
- Transspinal stimulation preceding assisted step training reorganizes neuronal excitability and function of inhibitory networks in spinal cord injury: a randomized controlled trial.Frontiers in neurology · 2025Article
- Reliability of SCIseg Automated Measurement of Midsagittal Tissue Bridges in Spinal Cord Injuries Using an External Dataset.Topics in spinal cord injury rehabilitation · 2025Article
- Noninvasive Electrical Modalities to Alleviate Respiratory Deficits Following Spinal Cord Injury.Life (Basel, Switzerland) · 2024Review
- Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential.Biomedicines · 2024Article
- Effects of Robotic Postural Stand Training with Epidural Stimulation on Sitting Postural Control in Individuals with Spinal Cord Injury: A Pilot Study.Journal of clinical medicine · 2024Article
- Targeted Selection of Stimulation Parameters for Restoration of Motor and Autonomic Function in Individuals With Spinal Cord Injury.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Individuals affected by motor complete spinal cord injury are unable to stand, walk, or move their lower limbs voluntarily; this diagnosis normally implies severe limitations for functional recovery. We have recently shown that the appropriate selection of epidural stimulation parameters was critical to promoting full-body, weight-bearing standing with independent knee extension in four individuals with chronic clinically complete paralysis. In the current study, we examined the effects of stand training and subsequent step training with epidural stimulation on motor function for standing in the same four individuals. After stand training, the ability to stand improved to different extents in the four participants. Step training performed afterwards substantially impaired standing ability in three of the four individuals. Improved standing ability generally coincided with continuous electromyography (EMG) patterns with constant levels of ground reaction forces. Conversely, poorer standing ability was associated with more variable EMG patterns that alternated EMG bursts and longer periods of negligible activity in most of the muscles. Stand and step training also differentially affected the evoked potentials amplitude modulation induced by sitting-to-standing transition. Finally, stand and step training with epidural stimulation were not sufficient to improve motor function for standing without stimulation. These findings show that the spinal circuitry of motor complete paraplegics can generate motor patterns effective for standing in response to task-specific training with optimized stimulation parameters. Conversely, step training can lead to neural adaptations resulting in impaired motor function for standing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.