Evidence map›Paper›PMID 27565967›Full record

ArticleHistochemistry and cell biology2017

Effect of irradiation/bone marrow transplantation on alveolar epithelial type II cells is aggravated in surfactant protein D deficient mice.

Christian Mühlfeld, Jens Madsen, Rose-Marie Mackay, Jan Philipp Schneider, Julia Schipke, Dennis Lutz, Bastian Birkelbach, Lars Knudsen, Marina Botto, Matthias Ochs and 1 more

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In one paragraph

Article in Histochemistry and cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. In focus in HCB.Histochemistry and cell biology · 2017
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Christian MühlfeldInstitute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
Jens MadsenChild Health, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.
Rose-Marie MackayChild Health, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.
Jan Philipp SchneiderInstitute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
Julia SchipkeInstitute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
Dennis LutzInstitute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
Bastian BirkelbachInstitute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
Lars KnudsenInstitute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
Marina BottoCentre for Complement and Inflammation Research, Division of Immunology and Inflammation, Faculty of Medicine, Imperial College London, Hammersmith Campus, London, W12 0NN, UK.
Matthias OchsInstitute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
Howard ClarkChild Health, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK. h.w.clark@soton.ac.uk.
Medizinische Hochschule Hannover · DESouthampton General Hospital · GBCentre for Inflammation Research · GBGerman Center for Lung Research · DEUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irradiation followed by bone marrow transplantation (BM-Tx) is a frequent therapeutic intervention causing pathology to the lung. Although alveolar epithelial type II (AE2) cells are essential for lung function and are damaged by irradiation, the long-term consequences of irradiation and BM-Tx are not well characterized. In addition, it is unknown whether surfactant protein D (SP-D) influences the response of AE2 cells to the injurious events. Therefore, wildtype (WT) and SP-D

Indexed as

Bone Marrow TransplantationGamma RaysAlveolar Epithelial CellsAnimalsMiceMice, Inbred C57BLMice, KnockoutPulmonary Surfactant-Associated Protein DWhole-Body IrradiationPulmonary Surfactant-Associated Protein DAlveolar epitheliumBone marrow transplantationDesign-based stereologyIrradiationSurfactant

Identifiers

PMID27565967
OpenAlexW2514520553

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.