SynthesisJournal of the National Cancer Institute2016
Pleiotropic Analysis of Lung Cancer and Blood Triglycerides.
Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of the National Cancer Institute, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00340340 (Genetic Epidemiology of Lung Cancer and Smoking; Current Title), which is not on this map. Cited by 16 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 16% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Lung Cancer and Smoking; Current Title: Environmental And Genetic Lung Cancer Etiology (EAGLE)
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Association between blood lipid levels and the risk of liver cancer: a systematic review and meta-analysis.Cancer causes & control : CCC · 2024Pooled it
- Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.Nature genetics · 2022Pooled it
- Association between triglyceride glucose index and risk of cancer: A meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Hypomethylation of FAM83A in lung adenocarcinoma mirrors an epigenetic signature of airway cell differentiation states.Discover oncology · 2026Article
- Association Between Metabolic Score for Insulin Resistance and the Incidence of Gastric Cancer in South Korea: A Nationwide Retrospective Study.Journal of clinical medicine · 2026Article
- Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription.World journal of gastrointestinal oncology · 2024Article
- Serum iron status and the risk of lung cancer: a two-sample Mendelian-randomization study.Journal of thoracic disease · 2023Article
- Article
- Identification of Tissue-Specific Gene Clusters Induced by DNA Demethylation in Lung Adenocarcinoma: More Than Germline Genes.Cancers · 2022Article
- Article
- Prognostic significance of preoperative serum triglycerides and high-density lipoproteins cholesterol in patients with non-small cell lung cancer: a retrospective study.Lipids in health and disease · 2021Article
- Triglyceride regulate ACE2 level through MTHFD1.Journal of biosciences · 2021Article
- Association Between Triglyceride Glucose Index and Non-Small Cell Lung Cancer Risk in Chinese Population.Frontiers in oncology · 2021Article
- Weak sharing of genetic association signals in three lung cancer subtypes: evidence at the SNP, gene, regulation, and pathway levels.Genome medicine · 2018Article
- Identification of shared genetic variants between schizophrenia and lung cancer.Scientific reports · 2018Article
- Association ofFrontiers in aging neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors at 4 institutions in 2 countries.
Verena ZuberNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Crystal N MarconettNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Jianxin ShiNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Xing HuaNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
William WheelerNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Chenchen YangNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Lei SongNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Anders M DaleNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Marina LaplanaNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Angela RischNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Aree WitoelarNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Wesley K ThompsonNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Andrew J SchorkNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Francesco BettellaNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Yunpeng WangNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Srdjan DjurovicNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Beiyun ZhouNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Zea BorokNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Henricus F M van der HeijdenNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Jacqueline de GraafNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Dorine SwinkelsNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Katja K AbenNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
James McKayNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Rayjean J HungNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Heike BikeböllerNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Victoria L StevensNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Demetrius AlbanesNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Neil E CaporasoNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Younghun HanNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Yongyue WeiNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Maria Angeles PanaderoNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Jose I MayordomoNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
David C ChristianiNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Lambertus KiemeneyNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Ole A AndreassenNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Richard HoulstonNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Christopher I AmosNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Nilanjan ChatterjeeNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Ite A Laird-OffringaNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Ian G MillsNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
Maria Teresa LandiNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine (VZ, AW, FB, YW, OAA), and Prostate Cancer Research Group, Centre for Molecular Medicine Norway, Nordic EMBL Partnership (VZ, IGM), University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (VZ, AW, FB, YW, OAA); European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK (VZ); Departments of Surgery and of Biochemistry and Molecular Biology (CNM, CY, IALO) and Will Rogers Institute Pulmonary Research Center and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (BZ, ZB), Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (CNM, CY, IALO); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, MD (JS, XH, LS, DA, NEC, NC, MTL); Information Management Services, Inc.; Rockville, MD (WW); Multimodal Imaging Laboratory (AMD, AJS), Center for Human Development (AMD, AJS), Department of Radiology (AMD), Department of Neurosciences (AMD), Department of Psychiatry (WKT), and Cognitive Sciences Graduate Program (AJS), University of California, San Diego, La Jolla, CA; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany (ML, AR); Department of Molecular Biology, University of Salzburg, Salzburg, Austria (AR); Translational Lung Research Center Heidelberg TLRC-H, Member of the German Center for Lung Research DZL, Heidelberg, Germany (AR); Department of Medical Genetics (SD) and Department of Molecular Oncology, Institute of Cancer Research and Department of Urology (IGM), Oslo University Hospital, Oslo, Norway (SD); NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway (SD); Radboud Unive
University of Oslo · NOHeidelberg University · DEOslo University Hospital · NOUniversity Hospital Heidelberg · DE
Funding
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4MTranslational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MRole of Chaperone GRP78 and Mitochondrial Dysfunction in ER Stress-Mediated Pulmonary FibrosisR01HL114959 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANN, DAVID K., ZHOU, BEIYUN · 2013 to 2025
$4.2MEpigenetic profiling of human alveolar epithelial cells in health and diseaseR01HL114094 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BOROK, ZEA, OFFRINGA, ITE A · 2011 to 2015
$3.3MPolygenicity, Pleiotrophy and Power: Novel Statistical Methods for Gene DiscoveryR01GM104400 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THOMPSON, WESLEY KURT · 2014 to 2017
$1.6MU S-FINLAND STUDIES OF NUTRITION AND CANCERN01CN045165 · CN · NATIONAL PUBLIC HEALTH INSTITUTE · PI HEINONEN, OLLI P · 1985 to 1996
–CCR NIH HHS N01 RC037004NCI NIH HHS N01 CN045165NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA023108NCI NIH HHS R35 CA197449NCI NIH HHS U19 CA148127NHLBI NIH HHS R01 HL114094NHLBI NIH HHS R01 HL114959NIGMS NIH HHS R01 GM104400
Abstract
Epidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted pleiotropic analysis of genome-wide association studies of lung cancer (12 160 lung cancer case patients and 16 838 control subjects) and cardiovascular disease risk factors (blood lipids from 188 577 subjects, type 2 diabetes from 148 821 subjects, body mass index from 123 865 subjects, and smoking phenotypes from 74 053 subjects). We found that 6p22.1 (rs6904596, ZNF184) was associated with both lung cancer (P = 5.50x10(-6)) and blood triglycerides (P = 1.39x10(-5)). We replicated the association in 6097 lung cancer case patients and 204 657 control subjects (P = 2.40 × 10(-4)) and in 71 113 subjects with triglycerides data (P = .01). rs6904596 reached genome-wide significance in lung cancer meta-analysis (odds ratio = 1.15, 95% confidence interval = 1.10 to 1.21 ,: Pcombined = 5.20x10(-9)). The large sample size provided by the lipid GWAS data and the shared genetic risk factors between the two traits contributed to the uncovering of a hitherto unidentified genetic locus for lung cancer.
Indexed as
Genetic PleiotropyCardiovascular DiseasesCase-Control StudiesChromosomes, Human, Pair 6Genome-Wide Association StudyHumansLung NeoplasmsMeta-Analysis as TopicPolymorphism, Single NucleotideRisk FactorsTriglyceridesTriglycerides
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT00340340ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.