Evidence map›Paper›PMID 27565788›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2017

2016 updated MASCC/ESMO consensus recommendations: Prevention of acute chemotherapy-induced nausea and vomiting in children.

L Lee Dupuis, Lillian Sung, Alexander Molassiotis, Andrea D Orsey, Wim Tissing, Marianne van de Wetering

Registry-linked trialAbstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06485869 (Impact of Virtual Reality on the Quality of Life of Oncology Patients), which is not on this map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06485869 narecruitingnot on this mapstarted 2023, after this paper: background citation

Impact of Virtual Reality on the Quality of Life of Oncology Patients

TypeinterventionalSponsorCentral Hospital Saint QuentinRan2023 to 2026Enrolled150ConditionsCancerArmsMeasure the improvement in quality of life, Measure the level of satisfaction of patients and nursing staff, Measurement of anxiety and pain, Measurement of depressive state, measuring fatigue levels
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Antiemetic medications for preventing chemotherapy-induced nausea and vomiting in children: a systematic review and Bayesian network meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  2. Palonosetron for prevention of delayed chemotherapy-induced nausea and vomiting in pediatric patients: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  3. Pooled it
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  14. Comment on 'risk factors associated with nausea and vomiting in children with cancer receiving chemotherapy'.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2023
    Article
  15. Review
  16. Article
  17. Article
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  20. Creation of a chemotherapy-induced nausea/vomiting dashboard to improve outcomes for pediatric cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

L Lee DupuisDepartment of Pharmacy and Research Institute, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada. lee.dupuis@sickkids.ca.
Lillian SungDepartment of Pediatrics and Research Institute, The Hospital for Sick Children, Toronto, Canada.
Alexander MolassiotisSchool of Nursing and WHO Collaborating Centre for Community Health Services, The Hong Kong Polytechnic University, Hong Kong, China.
Andrea D OrseyDivision of Pediatric Hematology/Oncology, Connecticut Children's Medical Center, Hartford, CT, USA.
Wim TissingDepartment of Pediatric Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Marianne van de WeteringDepartment of Paediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo update the 2009 recommendations for the prevention of acute chemotherapy-induced emesis in children.

methodsWe updated the original systematic literature search. Randomized studies were included in the evidence to support this guideline if they were primary studies fully published in full text in English or French; included only children less than 18 years old or, for mixed studies of adults and children, reported the pediatric results separately or the median or mean age was no more than 13 years; evaluated acute chemotherapy-induced nausea and vomiting (CINV) prophylaxis; provided sufficient information to permit determination of the emetogenicity of the antineoplastic therapy administered or the study investigators stated the emetogenicity of the chemotherapy administered; included an implicit or explicit definition of complete acute CINV response; described the antiemetic regimen in full; and reported the complete acute CINV response rate as a proportion.

resultsTwenty-five randomized studies, including eight published since 2009, met the criteria for inclusion in this systematic review. Prophylaxis with a 5-HT3 antagonist (granisetron or ondansetron or palonosetron or tropisetron) ± dexamethasone ± aprepitant is recommended for children receiving highly or moderately emetogenic chemotherapy. For children receiving chemotherapy of low emetogenicity, a 5-HT3 antagonist is recommended.

conclusionsThe findings of several randomized trials were used to update recommendations for the prevention of acute CINV. However, significant research gaps remain and must be addressed before CINV control in children can be optimized.

Indexed as

AntiemeticsAntineoplastic AgentsChildHumansNauseaPractice Guidelines as TopicRandomized Controlled Trials as TopicVomitingAntiemeticsAntineoplastic AgentsAntiemeticsChemotherapy-induced nauseaChemotherapy-induced vomitingPediatricsSupportive care

Identifiers

PMID27565788

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.