Chlorobaculum tepidum Modulates Amino Acid Composition in Response to Energy Availability, as Revealed by a Systematic Exploration of the Energy Landscape of Phototrophic Sulfur Oxidation.

Amalie T Levy, Kelvin H Lee, Thomas E Hanson

Open access · bronzeAbstract read

In one paragraph

Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Differential RNA Sequencing Implicates Sulfide as the Master Regulator of SApplied and environmental microbiology · 2018
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Amalie T LevyDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA Delaware Biotechnology Institute, University of Delaware, Newark, Delaware, USA.ORCID 0000-0002-1521-658X

Kelvin H LeeDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA Delaware Biotechnology Institute, University of Delaware, Newark, Delaware, USA.ORCID 0000-0003-0908-2981

Thomas E HansonSchool of Marine Science and Policy, University of Delaware, Newark, Delaware, USA Department of Biological Sciences, University of Delaware, Newark, Delaware, USA Delaware Biotechnology Institute, University of Delaware, Newark, Delaware, USA tehanson@udel.edu.ORCID 0000-0002-1967-5986

Biotechnology Institute · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Anjana Narayan Bhat · 2012 to 2026

$67.2M

NIGMS NIH HHS P20 GM103446

6 · The paper itself

Abstract

Microbial sulfur metabolism, particularly the formation and consumption of insoluble elemental sulfur (S IMPORTANCE: How microbes cope with and adapt to varying energy availability is an important factor in understanding microbial ecology and in designing efficient biotechnological processes. We explored the response of a model phototrophic organism, Chlorobaculum tepidum, across a factorial experimental design that enabled simultaneous variation and analysis of multiple growth conditions, what we term the "energy landscape." C. tepidum biomass composition shifted toward less energetically expensive amino acids at low light levels. This observation provides experimental evidence for evolved efficiencies in microbial proteomes and emphasizes the role that energy flux may play in the adaptive responses of organisms. From a practical standpoint, our data suggest that bulk biomass amino acid composition could provide a simple proxy to monitor and identify energy stress in microbial systems.

Indexed as

Phototrophic ProcessesAmino AcidsBiomassChlorobiElectronsLightOxidation-ReductionProteomeStress, PhysiologicalSulfurAmino AcidsProteomeSulfur

Identifiers

PMID27565613

DOI10.1128/AEM.02111-16

PMCPMC5066360

OpenAlexW2507310252

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.