Evidence map›Paper›PMID 27565578›Full record

ArticleMolecular and cellular neurosciences2016

The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains.

Emilia Laudati, Andrew S Gilder, Michael S Lam, Roberta Misasi, Maurizio Sorice, Steven L Gonias, Elisabetta Mantuano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  8. One Raft to Guide Them All, and in Axon Regeneration Inhibit Them.International journal of molecular sciences · 2021
    Review
  9. A soluble derivative of PrPThe Journal of biological chemistry · 2020
    Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Emilia LaudatiDepartment of Pathology, University of California San Diego, La Jolla, CA, USA; Institute of Pharmacology, Catholic University Medical School, Rome, Italy.
Andrew S GilderDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Michael S LamDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Roberta MisasiDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Maurizio SoriceDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Steven L GoniasDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Elisabetta MantuanoDepartment of Pathology, University of California San Diego, La Jolla, CA, USA; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. Electronic address: emantuano@ucsd.edu.
University of California San Diego · USSapienza University of Rome · IT

Funding

REGULATION OF UROKINASE RECEPTOR ACTIVITY BY LRPR01HL060551 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GONIAS, STEVEN L. · 1999 to 2014
$4.0M
NHLBI NIH HHS R01 HL060551
6 · The paper itself

Abstract

LDL Receptor-related Protein-1 (LRP1) is an endocytic receptor for diverse ligands. In neurons and neuron-like cells, ligand-binding to LRP1 initiates cell-signaling. Herein, we show that in PC12 and N2a neuron-like cells, LRP1 distributes into lipid rafts and non-raft plasma membrane fractions. When lipid rafts were disrupted, using methyl-β-cyclodextrin or fumonisin B1, activation of Src family kinases and ERK1/2 by the LRP1 ligands, tissue-type plasminogen activator and activated α

Indexed as

Animalsbeta-CyclodextrinsCells, CulturedEndocytosisFumonisinsLow Density Lipoprotein Receptor-Related Protein-1Membrane MicrodomainsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NeuronsPC12 CellsRatsRats, Sprague-Dawleysrc-Family KinasesTissue Plasminogen Activatorbeta-Cyclodextrinsfumonisin B1FumonisinsLow Density Lipoprotein Receptor-Related Protein-1methyl-beta-cyclodextrinMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3src-Family KinasesTissue Plasminogen ActivatorCell signalingEndocytosisLDL Receptor-related Protein-1 (LRP1)Lipid raftsNeurite outgrowthPlasma membraneTissue plasminogen activator (tPA)

Identifiers

PMID27565578
PMCPMC5056852
OpenAlexW2508874088

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.