ArticleNeuropharmacology2017
Modulating synaptic NMDA receptors.
Article in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Ion flux-independent NMDA receptor signaling.Neuropharmacology · 2022Review
- Recent Investigations on Neurotransmitters' Role in Acute White Matter Injury of Perinatal Glia and Pharmacotherapies-Glia Dynamics in Stem Cell Therapy.Molecular neurobiology · 2022Review
- Regulation of the NMDA receptor by its cytoplasmic domains: (How) is the tail wagging the dog?Neuropharmacology · 2021Review
- Targeting Ionotropic Glutamate Receptors in the Treatment of Epilepsy.Current neuropharmacology · 2021Review
- A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons.Cerebral cortex communications · 2020Article
- Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors.Science translational medicine · 2019Article
- Preferential enhancement of GluN2B-containing native NMDA receptors by the endogenous modulator 24S-hydroxycholesterol in hippocampal neurons.Neuropharmacology · 2019Article
- The Role of NMDA Receptors in Alzheimer's Disease.Frontiers in neuroscience · 2019Review
- Potential and Challenges for the Clinical Use of d-Serine As a Cognitive Enhancer.Frontiers in psychiatry · 2018Review
- Modulating GluN2B for the Treatment of Neurological and Psychiatric Disorders.ACS medicinal chemistry letters · 2017Article
- Pyrazole Inhibitors of GluN2B NMDA Receptor Subunit.ACS medicinal chemistry letters · 2016Article
- Impact of NMDA Receptor Overexpression on Cerebellar Purkinje Cell Activity and Motor Learning.eNeuroArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Recent structural information on ligand-gated glutamate receptors and newly-discovered clinical uses for NMDA receptor antagonists has renewed interest in understanding the mechanisms of drug action at these receptors. Although the voltage-dependence and calcium permeability of NMDA receptors are well-studied, the mechanisms affecting the time course of synaptic NMDA receptor activation may be of more therapeutic value by serving as a rheostat for the total synaptic response. The NMDA receptor-mediated EPSC time course has been thought of as a fixed parameter based simply on receptor subunit composition as variably constrained by anatomical and developmental expression patterns, albeit subject to modification by kinetic behaviors such as modal gating. However, the EPSC time course also can be manipulated by endogenous and exogenous ligands. In this commentary we discuss insights into the in situ composition and kinetic behavior of synaptic NMDA receptors and propose new opportunities to target modulatory sites on NMDA receptors and to develop useful therapeutics. The emerging data on the atomic structure of NMDA receptors and knowledge of the kinetics of native receptors in neurons provide a roadmap in this regard. This article is part of the Special Issue entitled 'Ionotropic glutamate receptors'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.