Evidence map›Paper›PMID 27565451›Full record

ArticleAndrology2016

Diagnostic value of qualitative and strain ratio elastography in the differential diagnosis of non-palpable testicular lesions.

C Pozza, D Gianfrilli, G Fattorini, E Giannetta, F Barbagallo, E Nicolai, C Cristini, G B Di Pierro, G Franco, A Lenzi and 3 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Andrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07099456 (Channelling Fertility And Sexual Function In Congenital Adrenal Hyperplasia. CALLIOPE), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07099456 recruitingnot on this mapstarted 2024, after this paper: background citation

Channelling Fertility And Sexual Function In Congenital Adrenal Hyperplasia. CALLIOPE: An Observational, Longitudinal Pilot Study

TypeobservationalSponsorUniversity of Roma La SapienzaRan2024 to 2030Enrolled50ConditionsCongenital Adrenal Hyperplasia (CAH)
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

C PozzaDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
D GianfrilliDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
G FattoriniDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
E GiannettaDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
F BarbagalloDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
E NicolaiSDN IRCC, Naples, Italy.
C CristiniDepartment of Urology, Sapienza University of Rome, Rome, Italy.
G B Di PierroDepartment of Urology, Sapienza University of Rome, Rome, Italy.
G FrancoDepartment of Urology, Sapienza University of Rome, Rome, Italy.
A LenziDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
P S SidhuDepartment of Radiology, King's College Hospital, London, England.
V CantisaniDepartment of Radiologic Science, Sapienza University of Rome, Rome, Italy.
A M IsidoriDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITKing's College Hospital · GBSDN Istituto di Ricerca Diagnostica e Nucleare · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to evaluate prospectively the accuracy of qualitative and strain ratio elastography (SE) in the differential diagnosis of non-palpable testicular lesions. The local review board approved the protocol and all patients gave their consent. One hundred and six patients with non-palpable testicular lesions were consecutively enrolled. Baseline ultrasonography (US) and SE were correlated with clinical and histological features and ROC curves developed for diagnostic accuracy. The non-palpable lesions were all ≤1.5 cm; 37/106 (34.9%) were malignant, 38 (35.9%) were benign, and 31 (29.2%) were non-neoplastic. Independent risk factors for malignancy were as follows: size (OR 17.788; p = 0.002), microlithiasis (OR 17.673, p < 0.001), intralesional vascularization (OR 9.207, p = 0.006), and hypoechogenicity (OR, 11.509, p = 0.036). Baseline US had 89.2% sensitivity (95% CI 74.6-97.0) and 85.5% specificity (95% CI 75.0-92.8) in identifying malignancies, and 94.6% sensitivity (95% CI 86.9-98.5) and 87.1% specificity (95% CI 70.2-96.4) in discriminating neoplasms from non-neoplastic lesions. An elasticity score (ES) of 3 out of 3 (ES3, maximum hardness) was recorded in 30/37 (81.1%) malignant lesions (p < 0.001). An intermediate score of 2 (ES2) was recorded in 19/38 (36.8%) benign neoplastic lesions and in 22/31 (71%) non-neoplastic lesions (p = 0.005 and p = 0.001 vs. malignancies). None of the non-neoplastic lesions scored ES3. Logistic regression analysis revealed a significant association between ES3 and malignancy (χ

Indexed as

Elasticity Imaging TechniquesAdolescentAdultDiagnosis, DifferentialHumansMaleMiddle AgedTesticular DiseasesTestisUltrasonographyYoung AdultLeydig cell tumormale infertilityscrotal ultrasoundseminomastrain elastographytesticular cancer

Identifiers

PMID27565451
PMCPMC5108442
OpenAlexW2511923075

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.