Evidence map›Paper›PMID 27565338›Full record

ArticleCell2016

Tag Team Ubiquitin Ligases.

Gary Kleiger, Raymond Deshaies

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. The von Hippel-Lindau Cullin-RING E3 ubiquitin ligase regulates APOBEC3 cytidine deaminases.Translational research : the journal of laboratory and clinical medicine · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Gary KleigerDepartment of Chemistry and Biochemistry, University of Nevada, Las Vegas, 4505 South Maryland Parkway, Las Vegas, NV 89154, USA.
Raymond DeshaiesDivision of Biology and Biological Engineering, California Institute of Technology, 1200 East California Blvd, Pasadena, CA 91125, USA; Howard Hughes Medical Institute. Electronic address: deshaies@caltech.edu.
California Institute of Technology · USUniversity of Nevada, Las Vegas · US

Funding

Regulation of cullin - RING ubiquitin ligasesR01GM065997 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI DESHAIES, RAYMOND J · 2002 to 2018
$4.5M
NIGMS NIH HHS R01 GM065997
6 · The paper itself

Abstract

Cullin-RING (CRL) and RING1-IBR-RING2 (RBR) are two distinct types of ubiquitin ligases. In this issue, Scott et al. show that CRLs activate the RBR enzyme ARIH1 to initiate ubiquitin chains on CRL substrates, thereby marking an unexpected and important advance in our understanding of both enzymes.

Indexed as

UbiquitinUbiquitin-Protein LigasesCullin ProteinsHumansCullin ProteinsUbiquitinUbiquitin-Protein Ligases

Identifiers

PMID27565338
OpenAlexW2508971891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.